ID A0A2F0B7H8_ESCRO Unreviewed; 195 AA.
AC A0A2F0B7H8;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Ileal sodium/bile acid cotransporter {ECO:0000256|ARBA:ARBA00013351};
DE AltName: Full=Apical sodium-dependent bile acid transporter {ECO:0000256|ARBA:ARBA00032438};
DE AltName: Full=Ileal Na(+)/bile acid cotransporter {ECO:0000256|ARBA:ARBA00033223};
DE AltName: Full=Ileal sodium-dependent bile acid transporter {ECO:0000256|ARBA:ARBA00030792};
DE AltName: Full=Na(+)-dependent ileal bile acid transporter {ECO:0000256|ARBA:ARBA00033014};
DE AltName: Full=Solute carrier family 10 member 2 {ECO:0000256|ARBA:ARBA00031381};
DE Flags: Fragment;
GN ORFNames=ESR_20842 {ECO:0000313|EMBL:MBV98925.1};
OS Eschrichtius robustus (California gray whale) (Eschrichtius gibbosus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Eschrichtiidae; Eschrichtius.
OX NCBI_TaxID=9764 {ECO:0000313|EMBL:MBV98925.1, ECO:0000313|Proteomes:UP000243164};
RN [1] {ECO:0000313|Proteomes:UP000243164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=29297306;
RA Moskalev A.A., Kudryavtseva A.V., Grafodatsky A.S., Beklemisheva V.R.,
RA Serdyukova N.A., Krutovsky K.V., Sharov V.V., Kulakovsky I.V., Lando A.S.,
RA Kasianov A.S., Snezhkina A.V., Kuzmin D.A., Putintseva J.A.,
RA Feranchuk S.I., Shaposhnikov M.V., Fraifeld V., Toren M., Sitnik V.V.;
RT "De novo assembling and primary analysis of genome and transcriptome of
RT gray whale Eschrichtius robustus.";
RL BMC Evol. Biol. 17:258-258(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauro-beta-muricholate(out) = 2 Na(+)(in) +
CC tauro-beta-muricholate(in); Xref=Rhea:RHEA:72179, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:133064; Evidence={ECO:0000256|ARBA:ARBA00034255};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) +
CC tauroallocholate(in); Xref=Rhea:RHEA:51840, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:191406; Evidence={ECO:0000256|ARBA:ARBA00034234};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) +
CC taurochenodeoxycholate(in); Xref=Rhea:RHEA:71923, ChEBI:CHEBI:9407,
CC ChEBI:CHEBI:29101; Evidence={ECO:0000256|ARBA:ARBA00034224};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) +
CC taurocholate(in); Xref=Rhea:RHEA:71875, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:36257; Evidence={ECO:0000256|ARBA:ARBA00034239};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurodeoxycholate(out) = 2 Na(+)(in) +
CC taurodeoxycholate(in); Xref=Rhea:RHEA:72087, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:36261; Evidence={ECO:0000256|ARBA:ARBA00034280};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) +
CC tauronorcholate(in); Xref=Rhea:RHEA:71915, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:191405; Evidence={ECO:0000256|ARBA:ARBA00034291};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauroursodeoxycholate(out) = 2 Na(+)(in) +
CC tauroursodeoxycholate(in); Xref=Rhea:RHEA:71927, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:132028; Evidence={ECO:0000256|ARBA:ARBA00034230};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in);
CC Xref=Rhea:RHEA:71911, ChEBI:CHEBI:29101, ChEBI:CHEBI:29747;
CC Evidence={ECO:0000256|ARBA:ARBA00034231};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2
CC Na(+)(in); Xref=Rhea:RHEA:71935, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29746; Evidence={ECO:0000256|ARBA:ARBA00034215};
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000256|ARBA:ARBA00011407}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBV98925.1}.
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DR EMBL; NTJE010091869; MBV98925.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2F0B7H8; -.
DR Proteomes; UP000243164; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR10361:SF19; ILEAL SODIUM_BILE ACID COTRANSPORTER; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000243164};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:MBV98925.1"
FT NON_TER 195
FT /evidence="ECO:0000313|EMBL:MBV98925.1"
SQ SEQUENCE 195 AA; 21046 MW; EEC4DCD308C313B1 CRC64;
MNNSTVCLAN ATVCDGASCV VPESDFNTTL SVVLSTVLTI LLSLVMFSMG CNVEIKKFLG
HIKQPWGICV GFLCQFGIMP LTGFVLSVTF DILPIQAVVV LIMGCCPGGT TSNILAYWAD
GDMDLSISMT TCSTLLALGM MPLCLLIYTK MWVDSGIILI PYDKIGISLV TLIVPVSIGM
FVNHRWPQKA KIILK
//
