ID A0A2F0BLE5_ESCRO Unreviewed; 279 AA.
AC A0A2F0BLE5;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Cathepsin L1 {ECO:0000313|EMBL:MBW03741.1};
DE Flags: Fragment;
GN ORFNames=ESR_10860 {ECO:0000313|EMBL:MBW03741.1};
OS Eschrichtius robustus (California gray whale) (Eschrichtius gibbosus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Eschrichtiidae; Eschrichtius.
OX NCBI_TaxID=9764 {ECO:0000313|EMBL:MBW03741.1, ECO:0000313|Proteomes:UP000243164};
RN [1] {ECO:0000313|Proteomes:UP000243164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=29297306;
RA Moskalev A.A., Kudryavtseva A.V., Grafodatsky A.S., Beklemisheva V.R.,
RA Serdyukova N.A., Krutovsky K.V., Sharov V.V., Kulakovsky I.V., Lando A.S.,
RA Kasianov A.S., Snezhkina A.V., Kuzmin D.A., Putintseva J.A.,
RA Feranchuk S.I., Shaposhnikov M.V., Fraifeld V., Toren M., Sitnik V.V.;
RT "De novo assembling and primary analysis of genome and transcriptome of
RT gray whale Eschrichtius robustus.";
RL BMC Evol. Biol. 17:258-258(2017).
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MBW03741.1}.
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DR EMBL; NTJE010279472; MBW03741.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2F0BLE5; -.
DR Proteomes; UP000243164; Unassembled WGS sequence.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF57; CATHEPSIN L2; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000243164};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 59..278
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:MBW03741.1"
SQ SEQUENCE 279 AA; 30930 MW; 246954C42C44BF15 CRC64;
MKMIDLHNQE YSQGKHGFTM AMNAFGDMTS EEFKQVMNGF QNQKHKKGKV FHEPLFLEVP
KSVDWTKKGY VTPVKNQGQC GSCWAFSATG ALEGQMFWKT GKLVSLSEQN LVDCSRPQGN
EGCSGGLMDN AFQYVKDNGG LDSEESYPYL GRETNSCNYK PECSAVNDTG FVDIPQREKA
LMKAVATVGP ISVAIDAGHT SFQFYKSGIY YDSDCSSKDL DHGVLVVGYG FEGKDSNNNK
FWIVKNSWGP EWGWNGYVKM AKDENNHCGI ATAASYPIV
//
