ID   A0A2G0CJN7_9BACT        Unreviewed;       925 AA.
AC   A0A2G0CJN7;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE            EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN   ORFNames=CGL56_03845 {ECO:0000313|EMBL:PHL00182.1};
OS   Neolewinella marina.
OC   Bacteria; Bacteroidota; Saprospiria; Saprospirales; Lewinellaceae;
OC   Neolewinella.
OX   NCBI_TaxID=438751 {ECO:0000313|EMBL:PHL00182.1, ECO:0000313|Proteomes:UP000226437};
RN   [1] {ECO:0000313|EMBL:PHL00182.1, ECO:0000313|Proteomes:UP000226437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MKG-38 {ECO:0000313|EMBL:PHL00182.1,
RC   ECO:0000313|Proteomes:UP000226437};
RA   Wang K.;
RT   "The draft genome sequence of Lewinella marina KCTC 32374.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PHL00182.1}.
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DR   EMBL; PDLO01000001; PHL00182.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G0CJN7; -.
DR   OrthoDB; 9759785at2; -.
DR   Proteomes; UP000226437; Unassembled WGS sequence.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000226437};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          582..775
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   925 AA;  104679 MW;  16352BB4971221CB CRC64;
     MSNYSHLANA HPGYIEQLYR QYSESPDSVD ASWRDFFLGF DYASEKSPTG PGMPTTPEGT
     IDWEHVKKEL SVFALIKAYR MRGHVASNID PIQEFEDPDA GLELSDFDLG EEDLDKPFRA
     ADQFFMPEGS TLRQIVDNLK RIYLGSIGFE TDHIFHREKR RWLRERIEKH HPEEAYGLQL
     DDKRHILETL NDAVGFEDFL KTKYPAQKRF GLEGGEAAIV ALNTIISEAA RDGVEEVVIG
     MAHRGRLNVL ANIMGKSYES IFQEFEGVIP DNIKGDGDVK YHMGYSSLIE TRVGKPVNVK
     LAPNPSHLEA VAPVVEGFAR AKADVLYGND YDKIVPILVH GDAAVAGQGV VFETAQMSGL
     EAYTTGGSIH LIINNQIGFT TDYEDARTSI YASGVATVIE APVFHVNGDD PEAVYYVAKL
     AMEYRNEFNS DVFIDMLCYR KNGHNEGDDP GYTQPGMYER VKRHPDVRQV YTDRLVARKD
     VQAKLAKEMA KKFKSRLQSV HTKVKNSDLP YSYQPPEKAW SMLNRDHWSY EHFSESPETG
     VPLEQMKNIL RHITTLPEGF EPVNKVNRLY NNYEQSVSSD QLDWALGELS AYATLLMDGH
     SVRMSGQDVR RGTFSHRHAV LKSQDGESIY NRLDGLSDDQ GKMHIYNSLL SEYAVLGFEY
     GYSTASPENL VIWEAQFGDF ANGAMTVFDQ FISSGESKWG RMSGLTVFLP HGYEGQGPEH
     SSARLERFLQ LCAEYNMVVA NVTMPANLFH LLRRQLTWNF RKPLILMSPK SGLRHEMAVS
     SIDDFGPGTR FQEVIDDPTV KDPAKVTRVL LCSGKVYFDL AKHKAAEEAE GVAIVRMEQL
     FPLPIRQLQE VRERYPNAKD YRWVQEESRN AGAWSYISEQ FLYNTDLGFE QKLDYVGRPA
     SASPATGYKP VHVKQQKRLV DQAFE
//