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Database: UniProt
Entry: A0A2G0Q441_9GAMM
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ID   A0A2G0Q441_9GAMM        Unreviewed;       340 AA.
AC   A0A2G0Q441;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00019465};
DE            EC=1.1.1.169 {ECO:0000256|ARBA:ARBA00013014};
DE   AltName: Full=Ketopantoate reductase {ECO:0000256|ARBA:ARBA00032024};
GN   ORFNames=Xhom_03055 {ECO:0000313|EMBL:PHM53985.1};
OS   Xenorhabdus hominickii.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=351679 {ECO:0000313|EMBL:PHM53985.1, ECO:0000313|Proteomes:UP000225433};
RN   [1] {ECO:0000313|EMBL:PHM53985.1, ECO:0000313|Proteomes:UP000225433}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17903 {ECO:0000313|EMBL:PHM53985.1,
RC   ECO:0000313|Proteomes:UP000225433};
RX   PubMed=28993611; DOI=10.1038/s41564-017-0039-9;
RA   Tobias N.J., Wolff H., Djahanschiri B., Grundmann F., Kronenwerth M.,
RA   Shi Y.M., Simonyi S., Grun P., Shapiro-Ilan D., Pidot S.J., Stinear T.P.,
RA   Ebersberger I., Bode H.B.;
RT   "Natural product diversity associated with the nematode symbionts
RT   Photorhabdus and Xenorhabdus.";
RL   Nat. Microbiol. 2:1676-1685(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.169; Evidence={ECO:0000256|ARBA:ARBA00000784};
CC   -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC       pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC       {ECO:0000256|ARBA:ARBA00004994}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PHM53985.1}.
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DR   EMBL; NJAI01000005; PHM53985.1; -; Genomic_DNA.
DR   RefSeq; WP_069318195.1; NZ_NJAI01000005.1.
DR   AlphaFoldDB; A0A2G0Q441; -.
DR   STRING; 351679.A9255_19705; -.
DR   KEGG; xho:A9255_19705; -.
DR   OrthoDB; 6530772at2; -.
DR   UniPathway; UPA00028; UER00004.
DR   Proteomes; UP000225433; Unassembled WGS sequence.
DR   GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR013332; KPR_N.
DR   PANTHER; PTHR21708:SF26; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR   PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pantothenate biosynthesis {ECO:0000256|ARBA:ARBA00022655}.
FT   DOMAIN          4..162
FT                   /note="Ketopantoate reductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02558"
FT   DOMAIN          193..312
FT                   /note="Ketopantoate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08546"
SQ   SEQUENCE   340 AA;  37847 MW;  CF25E77C661090D2 CRC64;
     MLRIGIIGTG AVACYLAHQC KQQGCQVFLL SSRGTRHQAQ PISQIQLIDE TKPEQAASQD
     LGSIVVDEHL TDYSAFLAKE FDQLYVCSKT VSNPHICQQL SRHKHWLRGP VILFQNGFAT
     ERPFIDEALD VTIIRGVLNF SVTQHGKQKL KLRFLKTSYL GVPEQTEERA EADILAALDL
     LNRAGIPFEG CTDIEHKAFA KNTLNAAASV CGLVRSGVET AMRNSSSRTV IQAIIDECTA
     IGEKAGYIGD SENFRRQSMG YLMSIPDFKS SLVLDILHGK ETEADTLLAS FIRLSQHVGI
     AVPNLDFVYR YFDFYNTYIT QSYITQSYTF TDMTLVEGDA
//
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