ID A0A2G0Q8Z3_9GAMM Unreviewed; 399 AA.
AC A0A2G0Q8Z3;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=AcrA {ECO:0000313|EMBL:PHM55629.1};
GN ORFNames=Xhom_02377 {ECO:0000313|EMBL:PHM55629.1};
OS Xenorhabdus hominickii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=351679 {ECO:0000313|EMBL:PHM55629.1, ECO:0000313|Proteomes:UP000225433};
RN [1] {ECO:0000313|EMBL:PHM55629.1, ECO:0000313|Proteomes:UP000225433}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17903 {ECO:0000313|EMBL:PHM55629.1,
RC ECO:0000313|Proteomes:UP000225433};
RX PubMed=28993611; DOI=10.1038/s41564-017-0039-9;
RA Tobias N.J., Wolff H., Djahanschiri B., Grundmann F., Kronenwerth M.,
RA Shi Y.M., Simonyi S., Grun P., Shapiro-Ilan D., Pidot S.J., Stinear T.P.,
RA Ebersberger I., Bode H.B.;
RT "Natural product diversity associated with the nematode symbionts
RT Photorhabdus and Xenorhabdus.";
RL Nat. Microbiol. 2:1676-1685(2017).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHM55629.1}.
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DR EMBL; NJAI01000003; PHM55629.1; -; Genomic_DNA.
DR RefSeq; WP_069316815.1; NZ_NJAI01000003.1.
DR AlphaFoldDB; A0A2G0Q8Z3; -.
DR STRING; 351679.A9255_11405; -.
DR KEGG; xho:A9255_11405; -.
DR OrthoDB; 9800613at2; -.
DR Proteomes; UP000225433; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009636; P:response to toxic substance; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 66..296
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT DOMAIN 297..364
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
SQ SEQUENCE 399 AA; 43494 MW; 700269CDF2FEC1C1 CRC64;
MRKNRGVLPL VTLLVFSGSF ILSGCNDNKN TLPGATGGFV PEVDIVTLKA EPLTVITELP
GRTSSYRVAE VRPQVSGIIL KRNYKEGSDI VAGESLYQID PATYQTEYNK AKANLARAQA
NEKVSHLTVE RYKSLLGTQY VSKQEFDKAD SDYAQANADV QSAKAALESA QINLAYTKVT
SPISGRAGKS TVTEGALVSA GQPTALTIVQ QLDPIYVDIT QSSDDYLRFK NEIAKGTIQR
DQNKAKLRLI TDTGQEYSKE GYLEFSDVAV DETTGSITMR AVFPNPNEEL LPGMFVRSKL
EEGVRQNAIL IPQQAVTRTP RGQATTLIVN KDNKVELRNI NAAQAIGNKW LVTEGLKAGD
RVIVTGLQKI KPDDTVKPVE IDLNAKPTAN QAEPVKKPQ
//
