ID A0A2G0QB15_9GAMM Unreviewed; 684 AA.
AC A0A2G0QB15;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=Xhom_01898 {ECO:0000313|EMBL:PHM56410.1};
OS Xenorhabdus hominickii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=351679 {ECO:0000313|EMBL:PHM56410.1, ECO:0000313|Proteomes:UP000225433};
RN [1] {ECO:0000313|EMBL:PHM56410.1, ECO:0000313|Proteomes:UP000225433}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17903 {ECO:0000313|EMBL:PHM56410.1,
RC ECO:0000313|Proteomes:UP000225433};
RX PubMed=28993611; DOI=10.1038/s41564-017-0039-9;
RA Tobias N.J., Wolff H., Djahanschiri B., Grundmann F., Kronenwerth M.,
RA Shi Y.M., Simonyi S., Grun P., Shapiro-Ilan D., Pidot S.J., Stinear T.P.,
RA Ebersberger I., Bode H.B.;
RT "Natural product diversity associated with the nematode symbionts
RT Photorhabdus and Xenorhabdus.";
RL Nat. Microbiol. 2:1676-1685(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHM56410.1}.
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DR EMBL; NJAI01000002; PHM56410.1; -; Genomic_DNA.
DR RefSeq; WP_069316350.1; NZ_NJAI01000002.1.
DR AlphaFoldDB; A0A2G0QB15; -.
DR STRING; 351679.A9255_08630; -.
DR KEGG; xho:A9255_08630; -.
DR OrthoDB; 5298826at2; -.
DR Proteomes; UP000225433; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR022161; Helicase_IV_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12462; Helicase_IV_N; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 195..505
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 216..223
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 684 AA; 78766 MW; 9C776604C89B1EAE CRC64;
MELKSTQIGQ CLAQHPYNRV RLLNAGIEVS GDKHQYLIPF NQLLGIQCKR GIVWGELEFE
LLEGKVVRLH GTEWQQTQHF YHHLLKEWQK WSLDMSDVSA DALAAQMNEI DKVKQQKRWI
NAADLASLQQ QIQETFQSLP LPLQRITQFE NCRDDYQICL NWLDEGEKTV QTTNQQWIDH
MLVQYEEFFR TVEISPLNRT QCRAVINGEK NILVLAGAGS GKTSVLVARA GWLLLRQQAL
PEQVLLLAFG RQAADEMNER IQARLGTKAI KAKTFHALAL HIIQQGSNKE PKISELETDV
QKRRDFLIQE WQKQCGEKKA QAKGWREWLT EELDWQLSEG EYWHDKQLAL RLSVRLERWL
ELMRMNGSSQ KEMIEQAPSA YTSVFQKRVR LMAPLLKAWR AALKAEGAVD FSGLIHQAVN
ILEKGRFISP WKHILVDEFQ DISPLRAKLL TALKMQNKQS HLFAAGDDWQ AIYRFSGAEL
TLTTAFSDYF GKGAECTLDT TYRFSERIAE IANLFIQQNP SQLSKPLNSL VKGNKKSVVI
LPEEQLETLL NKMSGYVTKQ ETILLLARYH YLKPKLLKKA STRWPNLNIE FMTIHASKGQ
QADYVIILGL HHGQDGFPAP IRESVIEQAL LPKPEDFPDA EERRLLYVAL TRAKKQLWLM
QEPKNPSIFI HQLGKLGVPT QRKP
//
