ID A0A2G1MDH3_9RHOB Unreviewed; 481 AA.
AC A0A2G1MDH3;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=CJ301_15180 {ECO:0000313|EMBL:PHP26712.1};
OS Limimaricola cinnabarinus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Limimaricola.
OX NCBI_TaxID=1125964 {ECO:0000313|EMBL:PHP26712.1, ECO:0000313|Proteomes:UP000221860};
RN [1] {ECO:0000313|EMBL:PHP26712.1, ECO:0000313|Proteomes:UP000221860}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XM1 {ECO:0000313|EMBL:PHP26712.1,
RC ECO:0000313|Proteomes:UP000221860};
RA Ma R., Wang J., Wang Q., Ma Z., Li J., Chen L.;
RT "Draft Genome Sequence of Loktanella cinnabarina Strain XM1, Isolated from
RT Coastal Surface Water.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHP26712.1}.
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DR EMBL; NQWH01000030; PHP26712.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G1MDH3; -.
DR OrthoDB; 9806359at2; -.
DR Proteomes; UP000221860; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:PHP26712.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:PHP26712.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PHP26712.1}.
FT DOMAIN 6..291
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 326..476
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 481 AA; 51836 MW; F224EE6164DE1605 CRC64;
MTTITPVLLC GGSGTRLWPL SRKSYPKQFV PLMGEETLFQ ASARRLHGRG LGPDGDLGFA
SPLVLTNADF RFIVTEQLGL AGIDPRAVLI EPEGRNTAPA ILAAASYLVA SDPEAVMLVA
PSDHVVPDAA SFYAAVAQGL GPVREGRLVT FGIAPTHAET GYGYLELEGP VDDGAPQPLT
RFVEKPDLGR AEDMLASGNF LWNAGIFMAR AADMVAAFRE HGPEILGPVE AALAQAKTDL
GFLRLDPASW ATAPDISIDY AVMEKAPNLS VVPFSGEWSD LGGWDAVWRE SGPDESGVVT
SQGATAIDCR DTLLRSESDR LEIVGIGLEN VMAIAMNDAV LVADMSRAQD VKKAVEALKA
KQSPQATAFP KDHRPWGWFE SLVIGGRFQV KRIMVHPGAA LSLQSHHHRS EHWIVVEGTA
RVTIDDEVKL VTENQSVYVP LGAVHRMENP GKVPMVLIEV QTGAYVGEDD IVRYEDVYAR
N
//
