ID A0A2G1WM76_9EURY Unreviewed; 1211 AA.
AC A0A2G1WM76;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=DJ69_02555 {ECO:0000313|EMBL:PHQ40082.1};
OS Halorubrum persicum.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Halorubrum.
OX NCBI_TaxID=1383844 {ECO:0000313|EMBL:PHQ40082.1, ECO:0000313|Proteomes:UP000222824};
RN [1] {ECO:0000313|EMBL:PHQ40082.1, ECO:0000313|Proteomes:UP000222824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C49 {ECO:0000313|EMBL:PHQ40082.1,
RC ECO:0000313|Proteomes:UP000222824};
RX PubMed=24782836; DOI=10.3389/fmicb.2014.00140;
RA Fullmer M.S., Soucy S.M., Swithers K.S., Makkay A.M., Wheeler R.,
RA Ventosa A., Gogarten J.P., Papke R.T.;
RT "Population and genomic analysis of the genus Halorubrum.";
RL Front. Microbiol. 5:140-140(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHQ40082.1}.
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DR EMBL; NHOA01000017; PHQ40082.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G1WM76; -.
DR OrthoDB; 203178at2157; -.
DR Proteomes; UP000222824; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF23; RECBCD ENZYME SUBUNIT RECB; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 7..492
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 532..818
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 28..35
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1211 AA; 134716 MW; A76B549E02ACF2B1 CRC64;
MTEEPEEIQL TEEQEDALVQ GRNVAITAGA GTGKTTTLTE RYVTILAENP SLTPKNIVTI
TFTRKAAAEL TERVREEVYD RLEAVDSPQA YHRWRNVLDD LEDGYVHTIH AFCTRLLRER
AVEAPVPLGF DVLDEDGAAT LQREVVTEYL ERNQDDDDVA LLAQLWGRDQ LVDVLAGLLD
ERPQSEAVLE AWRDAEADDY VDICWEFVCD LDVADARQTL YADGLLDQLR TIAGRVDRED
TIADEDGLRA YQTFTEVATT LSDDLEESDP RDCQRAILEL YEACEKKNGG LYSSSGYVVG
DRDDWGEYGD VYDDLKDAID TVIDAVEPHA DAVETTPGEL EANSAHYALA LMRVFDDVLA
TYTDEKDRRD TLDFPDVIET TLEFLRTNDA VTERLREQFA AVMVDEFQDT DPRQWELVKL
LTGVDEQTAS NVFLVGDEKQ SIYGFRGADV TTFGEARAEL QTVNEARGVD DVPDSDAESP
TALELSGNFR TLDEPLSFLN ELFEYLFQPE GDSHEPHEAP PQELTTQRDR IEDIEGLTGS
VEYLAVPDDA DTAAELFGDD HPVAEGALDH TIEAEAQALA ARLTHLFDDP PQVQDPDTGV
HRDATPDDTA ILLRRRTHLD RYQRALEEYN IPYTVVGGVG FYDTPEVQAL TNLLRVLGDP
QDDVSLYGVL RSPLFGFADD RLAPAVAEAD SVWDALAETD DPQLADAFDL LTTWRTLSGC
ATPSEEGVLP WNRLLSRVID DTGYLASVSA DERGRQAVAN VEKFRDQVRT WTENGVHTAA
GLLHRIDRQA EIDPREGEAD IPGDAEGVRI MTIHSAKGLE FPIVTVPDLG SDLNFGRSVD
DYGYVRLVDG TDDAPPVPAV GGPNPGDTFS IEKTAVHEYA DRRSRPQERA ESKRLLYVAC
TRTRDHLLLC GTHDIDVDES GTIELGEPAA FDDADRWRDW LQPALLDGAL VAEAVRDGQA
RGEMDGASYT VRKPPRPVDW HTDDDAVDSA PEISIPSPPS LAPAKWIAAT TLVNAVADAS
PDSHSYTQRE ESAGLSPTTF GTVVHRINEL RPPRDEWPTL IRRLSRMSGE EPTEPDLRDA
VDHAADAVEF VDQVEADSQL QAVYDEYSVV ARIDESRIVG DIDRLLVTPD AFHIIDYKTN
DLSATTSGEL AEHYRPQMLA YALALLQHDR NRDVRASLRF TDAGVEERFH WVSDQMAEIE
SELRPMMDLV K
//
