ID A0A2G1XA13_STRCJ Unreviewed; 750 AA.
AC A0A2G1XA13;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Thioesterase domain-containing protein {ECO:0000259|Pfam:PF00975};
GN ORFNames=BLA24_31935 {ECO:0000313|EMBL:PHQ48062.1}, CYQ11_24990
GN {ECO:0000313|EMBL:PPT15688.1};
OS Streptomyces cinnamoneus (Streptoverticillium cinnamoneum).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces cinnamoneus group.
OX NCBI_TaxID=53446 {ECO:0000313|EMBL:PHQ48062.1, ECO:0000313|Proteomes:UP000222531};
RN [1] {ECO:0000313|EMBL:PHQ48062.1, ECO:0000313|Proteomes:UP000222531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 21532 {ECO:0000313|EMBL:PHQ48062.1,
RC ECO:0000313|Proteomes:UP000222531};
RX PubMed=29053243;
RA Patteson J., Cai W., Johnson R.A., Santa Maria K., Li B.;
RT "Identification of the Biosynthetic Pathway for the Antibiotic
RT Bicyclomycin.";
RL Biochemistry 0:0-0(2017).
RN [2] {ECO:0000313|EMBL:PPT15688.1, ECO:0000313|Proteomes:UP000239771}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 41675 {ECO:0000313|EMBL:PPT15688.1,
RC ECO:0000313|Proteomes:UP000239771};
RA Vior N.M., Lacret R., Chandra G., Dorai-Raj S., Trick M., Truman A.W.;
RT "Discovery and biosynthesis of the antibiotic bicyclomycin in distant
RT bacterial classes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M20A family.
CC {ECO:0000256|ARBA:ARBA00006247}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHQ48062.1}.
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DR EMBL; NHZO01000168; PHQ48062.1; -; Genomic_DNA.
DR EMBL; PKFQ01000001; PPT15688.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G1XA13; -.
DR OrthoDB; 7055905at2; -.
DR Proteomes; UP000222531; Unassembled WGS sequence.
DR Proteomes; UP000239771; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.900; -; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001261; ArgE/DapE_CS.
DR InterPro; IPR047177; Pept_M20A.
DR InterPro; IPR002933; Peptidase_M20.
DR InterPro; IPR001031; Thioesterase.
DR PANTHER; PTHR45962; N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1; 1.
DR PANTHER; PTHR45962:SF1; N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00758; ARGE_DAPE_CPG2_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000222531};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 18..233
FT /note="Thioesterase"
FT /evidence="ECO:0000259|Pfam:PF00975"
SQ SEQUENCE 750 AA; 79552 MW; 23950EB8F818142F CRC64;
MSTPWLRIHD DAQDGTLVVC FPPTGAHGAS FAGWRAALPA GTALALVAPP GRGSRMDEEP
VTGMAAYADA VAAGLRTAAR GRRLVLVGVS LGALLAYETC RRLLDADVPV ARLCVVAGQT
PGDFHGDGGE LTADDARAFV LRTGLTDPEL LADPDFEDVL LPPVLADLRL SGGYDGRHAP
ALPVRLRAVW ATDDEHVPRR AVEKWAAWTT LDCVVTAVEG GHYVHQEAPG AVVAACLDEH
VPTAGGPSRR TLLGAGVTAV AGAVLTPGTA TAARGRAAAP APHPFEGDPT DPLALAVAMI
RQNTSNPGDG AVTRPHALLL QGVFEAAGVA TEIVPTPKQD NVHFLARVPA ARPGGKKPLL
LLGHSDVVPA TGDTWTVEPF AGLVKDGMLY GRGALDMKGV TAAFVAALLR HVKEGTRFDR
DVVLWSDCDE EQGPHGVRWF LSEHPDKVDP GVVLTEGGWV LGQRDGKTPM IAALTCNDKR
SLLLRLETAS YATHTSKPFT GQAVTRLGQA LERLGGWRAH IRPNALSRQY FTELARATAD
PALAAAVRAM LDARTEAVRD RAGDEVVRLS DTPELHNAML RTTAAFTATS AGYYPSIVPG
TATAEFRVAF LPGGDDPGRT VAELRLLAGD GATLRVVGNP GETEEQAIDR LRGYLSVPDS
TADTDVFRAW QEAVRQTHPG IRASACQFEA VTSAVPFRER GVPVYGIYPF TVTRDMLRRM
HGTDEHIDVA ALRQGTETVY QLLGRLRAAP
//
