ID A0A2G1XGY0_STRCJ Unreviewed; 376 AA.
AC A0A2G1XGY0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing) {ECO:0000313|EMBL:PHQ50389.1};
GN ORFNames=BLA24_20845 {ECO:0000313|EMBL:PHQ50389.1}, CYQ11_09935
GN {ECO:0000313|EMBL:PPT16463.1};
OS Streptomyces cinnamoneus (Streptoverticillium cinnamoneum).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces cinnamoneus group.
OX NCBI_TaxID=53446 {ECO:0000313|EMBL:PHQ50389.1, ECO:0000313|Proteomes:UP000222531};
RN [1] {ECO:0000313|EMBL:PHQ50389.1, ECO:0000313|Proteomes:UP000222531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 21532 {ECO:0000313|EMBL:PHQ50389.1,
RC ECO:0000313|Proteomes:UP000222531};
RX PubMed=29053243;
RA Patteson J., Cai W., Johnson R.A., Santa Maria K., Li B.;
RT "Identification of the Biosynthetic Pathway for the Antibiotic
RT Bicyclomycin.";
RL Biochemistry 0:0-0(2017).
RN [2] {ECO:0000313|EMBL:PPT16463.1, ECO:0000313|Proteomes:UP000239771}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 41675 {ECO:0000313|EMBL:PPT16463.1,
RC ECO:0000313|Proteomes:UP000239771};
RA Vior N.M., Lacret R., Chandra G., Dorai-Raj S., Trick M., Truman A.W.;
RT "Discovery and biosynthesis of the antibiotic bicyclomycin in distant
RT bacterial classes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC {ECO:0000256|RuleBase:RU003513}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHQ50389.1}.
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DR EMBL; NHZO01000151; PHQ50389.1; -; Genomic_DNA.
DR EMBL; PKFQ01000001; PPT16463.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G1XGY0; -.
DR OrthoDB; 9803238at2; -.
DR Proteomes; UP000222531; Unassembled WGS sequence.
DR Proteomes; UP000239771; Unassembled WGS sequence.
DR GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
DR CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR InterPro; IPR029767; WecB-like.
DR NCBIfam; TIGR00236; wecB; 1.
DR PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR PANTHER; PTHR43174:SF1; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR Pfam; PF02350; Epimerase_2; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU003513};
KW Reference proteome {ECO:0000313|Proteomes:UP000222531}.
FT DOMAIN 34..363
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
SQ SEQUENCE 376 AA; 39423 MW; 1C0454161F3F7DD4 CRC64;
MSPLPPRSVA IVLGTRPELV KLTDLVRLLG PAAHLVHTGQ HYDEELSGRF LTELGLPEPT
FLTGVGGRPR AVQISAALAQ LDDLFTTEPP LAVVVQGDTN AALAGALAAN ARGIPLVHVE
AGLRSHDRAM PEEHNRVLID RLADVLCAAT EDNRANLLAE GVDDARVAVT GNTVVEAVLG
QLPGERERTR LLAGRGLTAD GYVLATVHRP ENTDAPDALR AILGELGALA TAGRPVVLPL
HPRTRGRIEA AGLTDLLAPL TVTAPLGYSE FLALARHAAL LVSDSGGIQE ECTVLGRPLV
VVRRSTERPE AMAEFADLVR PGREIGEAAR RRLAEGPEGL ARLAALPSPF GDGLASERIV
NLLVAIAAPA ELATAA
//
