ID A0A2G1XPY9_STRCJ Unreviewed; 407 AA.
AC A0A2G1XPY9;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Precorrin-6y C5,15-methyltransferase (Decarboxylating) subunit CbiE {ECO:0000313|EMBL:PHQ53304.1};
GN Name=cbiE {ECO:0000313|EMBL:PHQ53304.1};
GN ORFNames=BLA24_03090 {ECO:0000313|EMBL:PHQ53304.1}, CYQ11_05390
GN {ECO:0000313|EMBL:PPT12401.1};
OS Streptomyces cinnamoneus (Streptoverticillium cinnamoneum).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces cinnamoneus group.
OX NCBI_TaxID=53446 {ECO:0000313|EMBL:PHQ53304.1, ECO:0000313|Proteomes:UP000222531};
RN [1] {ECO:0000313|EMBL:PHQ53304.1, ECO:0000313|Proteomes:UP000222531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 21532 {ECO:0000313|EMBL:PHQ53304.1,
RC ECO:0000313|Proteomes:UP000222531};
RX PubMed=29053243;
RA Patteson J., Cai W., Johnson R.A., Santa Maria K., Li B.;
RT "Identification of the Biosynthetic Pathway for the Antibiotic
RT Bicyclomycin.";
RL Biochemistry 0:0-0(2017).
RN [2] {ECO:0000313|EMBL:PPT12401.1, ECO:0000313|Proteomes:UP000239771}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 41675 {ECO:0000313|EMBL:PPT12401.1,
RC ECO:0000313|Proteomes:UP000239771};
RA Vior N.M., Lacret R., Chandra G., Dorai-Raj S., Trick M., Truman A.W.;
RT "Discovery and biosynthesis of the antibiotic bicyclomycin in distant
RT bacterial classes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHQ53304.1}.
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DR EMBL; NHZO01000037; PHQ53304.1; -; Genomic_DNA.
DR EMBL; PKFQ01000001; PPT12401.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G1XPY9; -.
DR OrthoDB; 4327941at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000222531; Unassembled WGS sequence.
DR Proteomes; UP000239771; Unassembled WGS sequence.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF06325; PrmA; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:PHQ53304.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000222531};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PHQ53304.1}.
FT DOMAIN 15..182
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 407 AA; 42239 MW; 24D0EAB302E256E4 CRC64;
MADRVTVIGW DGSPLTDAAR SALAAATLVA GAAHHLALPE VPPAAERIRL GSVDLAARRI
AQHRGSAVVL ADGDPGFFGV LRTLRAPEHG LEVEVVPAVS SVATAFARTA MPWDDAQIVV
AHSRDLRRAV NVCRAHPKVA VLTSPGAGPA ELALLLGDVH RTFVICEELG TEREEVTVVT
SDRAADHTWR DPNVVIVIGG PGAAESRPKA GGGWIAGRDP GYPPALRGWA LRGGAYGDGL
GEGESTELRA AQLARLGPRV GDLVWDIGSG SGAAAVEAAR FGAAVIAVDR DPAACHRTTA
AARRHGVQLQ VVHGTAPQVL EDLPEPDVVR VGGGGAAVVA ACADRRPERI VAHAVTRDDA
EAIGRALAEG GYAAECTLLQ AVELDTAAWV ERERAVAFLL SGRRTHP
//
