ID A0A2G1XYC4_9GAMM Unreviewed; 722 AA.
AC A0A2G1XYC4;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=COA29_04330 {ECO:0000313|EMBL:PHQ56304.1};
OS Porticoccus sp.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Porticoccaceae; Porticoccus.
OX NCBI_TaxID=2024853 {ECO:0000313|EMBL:PHQ56304.1, ECO:0000313|Proteomes:UP000226842};
RN [1] {ECO:0000313|Proteomes:UP000226842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tully B.J., Wheat C.G., Glazer B.T., Huber J.A.;
RT "A dynamic microbial community with high functional redundancy inhabits the
RT cold, oxic subseafloor aquifer.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHQ56304.1}.
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DR EMBL; NVQM01000046; PHQ56304.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G1XYC4; -.
DR Proteomes; UP000226842; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 8..286
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 287..562
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 722 AA; 82169 MW; BF69B569BB42FB05 CRC64;
MDVTTILDPL NPAQREAVSS NASHLLVLAG AGSGKTRVLV HRIAWLIQVE QVSPYSIIAV
TFTNKAAREM RGRIEELLGF SARGMWVGTF HGLAHRLLKM HWQDAGLPEN FQILDSDDQL
RLVKRLYQSL GIDDSRWPHR QAQSFINNQK DEGLRSRDLQ PAHDPYQRTM QQVYAAYEEA
CERGGMVDFG ELLLRAHELW LKNPELLQHY QHRFQHLLAD EFQDTNAIQY AWLRVLAGDQ
VPVTAVGDDD QSIYGWRGAK VENIRYFSRD YPATQTVRLE QNYRSSKNIL EAANAVISRN
TNRLGKNLWT DDNEGEAISL YAAFNEQDEA RFIAERLREW VNQGNLREES AILYRSNAQS
RVLEEALLRA AIPYRIYGGQ KFYERQEIRN ALAYLRLLVN CHDDAAFERV VNTPTRGIGD
KTIQELRELA REEGMSLWRT AEHAIAAGRF SGRASNALEA FLKLLAKLGE ESAELPLHEL
VDHIIEGSGL IDFHRREKGD RGESRVENLQ ELVIACRSFE PEEKELPSLP QFLDRAALDA
GDRQADVGED AVQLMTLHSA KGLEFPLVFL AGMEENLFPH RMSAEDPNRL EEERRLAYVG
ITRAMQKLYL TFAESRQQYG IENYNRVSRF VRDIPANLVE EVRLRAQIKR PTSYARQPAM
NLSDSGEDTG LSLGQRVLHP IFGEGVVINF EGNGAHARVQ VNFDKEGTKW LVLAYAKLSP
VA
//
