ID   A0A2G1Z7P8_9PROT        Unreviewed;       393 AA.
AC   A0A2G1Z7P8;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=DNA gyrase subunit A {ECO:0000313|EMBL:PHQ71794.1};
DE   Flags: Fragment;
GN   ORFNames=COB93_02295 {ECO:0000313|EMBL:PHQ71794.1};
OS   Sneathiella sp.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sneathiellales;
OC   Sneathiellaceae; Sneathiella.
OX   NCBI_TaxID=1964365 {ECO:0000313|EMBL:PHQ71794.1, ECO:0000313|Proteomes:UP000224255};
RN   [1] {ECO:0000313|Proteomes:UP000224255}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Tully B.J., Wheat C.G., Glazer B.T., Huber J.A.;
RT   "A dynamic microbial community with high functional redundancy inhabits the
RT   cold, oxic subseafloor aquifer.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PHQ71794.1}.
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DR   EMBL; NVRR01000031; PHQ71794.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G1Z7P8; -.
DR   Proteomes; UP000224255; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          1..393
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   NON_TER         393
FT                   /evidence="ECO:0000313|EMBL:PHQ71794.1"
SQ   SEQUENCE   393 AA;  43625 MW;  46653F3543D1E723 CRC64;
     MRRSYLDYAM SVIVSRALPD ARDGLKPVHR RIIYAMYENG YTSDKAYRKS ARVVGDVMGR
     YHPHGDSAIY DAMVRLAQDF SMSLKLIEGQ GNFGSMDGDR AAAMRYTEAR LQKAAESLID
     DIDKETVDFV NNYDDSEREP SVLPARYPNL LVNGAGGIAV GMATNIPPHN LGEVIDGSIA
     LLENPELAVE ELLEHIPAPD FPTGGVILGR TGSISGLTTG RGSVIMRAKV DIEEIRKDRQ
     ALIVTEIPYQ VNKARLVEQI ADLVRAKKVE GIGDLRDESD RHGVRVVVEI KRDAMAEVVL
     NQLYRYTSLQ TSFGVNMLAL NRGKPELLNV KELLEAFLDF REEVVTRRTK YLLNKARERA
     HVLIGLAIAV ANIDEIIKLI RAAPDPVTAR SEL
//