ID A0A2G2VYZ9_CAPBA Unreviewed; 248 AA.
AC A0A2G2VYZ9;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=mRNA cap guanine-N7 methyltransferase 1 {ECO:0000313|EMBL:PHT38210.1};
GN ORFNames=CQW23_21783 {ECO:0000313|EMBL:PHT38210.1};
OS Capsicum baccatum (Peruvian pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=33114 {ECO:0000313|EMBL:PHT38210.1, ECO:0000313|Proteomes:UP000224567};
RN [1] {ECO:0000313|EMBL:PHT38210.1, ECO:0000313|Proteomes:UP000224567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PBC81 {ECO:0000313|Proteomes:UP000224567};
RC TISSUE=Leaf {ECO:0000313|EMBL:PHT38210.1};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
RN [2] {ECO:0000313|Proteomes:UP000224567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PBC81 {ECO:0000313|Proteomes:UP000224567};
RA Kim S., Park J., Yeom S.-I., Kim Y.-M., Seo E., Kim K.-T., Kim M.-S.,
RA Lee J.M., Cheong K., Shin H.-S., Kim S.-B., Han K., Lee J., Park M.,
RA Lee H.-A., Lee H.-Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E.,
RA Jeon J., Kim H., Choi G., Song H., Lee J., Lee S.-C., Kwon J.-K.,
RA Lee H.-Y., Koo N., Hong Y., Kim R.W., Kang W.-H., Huh J.H., Kang B.-C.,
RA Yang T.-J., Lee Y.-H., Bennetzen J.L., Choi D.;
RT "Multiple reference genome sequences of hot pepper reveal the massive
RT evolution of plant disease resistance genes by retroduplication.";
RL J. Anim. Genet. bioRxivorg:115410-115410(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA +
CC S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-
CC triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA-
CC COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461,
CC ChEBI:CHEBI:167617; EC=2.1.1.56;
CC Evidence={ECO:0000256|ARBA:ARBA00024288};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT38210.1}.
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DR EMBL; MLFT02000009; PHT38210.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G2VYZ9; -.
DR STRING; 33114.A0A2G2VYZ9; -.
DR Proteomes; UP000224567; Chromosome 9.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR004971; mRNA_G-N7_MeTrfase_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR35046:SF9; CCHC-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR35046; ZINC KNUCKLE (CCHC-TYPE) FAMILY PROTEIN; 1.
DR Pfam; PF03291; mRNA_G-N7_MeTrfase; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:PHT38210.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000224567};
KW Transferase {ECO:0000313|EMBL:PHT38210.1}.
FT DOMAIN 2..76
FT /note="Reverse transcriptase RNase H-like"
FT /evidence="ECO:0000259|Pfam:PF17917"
FT DOMAIN 55..217
FT /note="MRNA cap 0 methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF03291"
FT REGION 219..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 248 AA; 29359 MW; DC56AAE63605569D CRC64;
MKPLAFFSEK LSESRQKWST YQQELYSVYR ALKIWEVYLM PKEFIVCIDH QSLKHFRSQK
HVDRMLARWA AYLERFNYLI VHKSGVTNRA ADALSRRAGL TVSFETELPG VDQIKELYKN
DEDFGRIWVN KRKDAVDCPE WIVPFPVFKA MAEEYDFELV FVKNNHEFVD EYMKKPEFVE
LMRRLGALGD GNQDQSTLSP DEWEVAYLYL AFVLRKRGQP DQTRRNPRRD KGKMQLTKDN
IENVNGAV
//
