ID A0A2G2X4B5_CAPBA Unreviewed; 1438 AA.
AC A0A2G2X4B5;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CQW23_06762 {ECO:0000313|EMBL:PHT52300.1};
OS Capsicum baccatum (Peruvian pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=33114 {ECO:0000313|EMBL:PHT52300.1, ECO:0000313|Proteomes:UP000224567};
RN [1] {ECO:0000313|EMBL:PHT52300.1, ECO:0000313|Proteomes:UP000224567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PBC81 {ECO:0000313|Proteomes:UP000224567};
RC TISSUE=Leaf {ECO:0000313|EMBL:PHT52300.1};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
RN [2] {ECO:0000313|Proteomes:UP000224567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PBC81 {ECO:0000313|Proteomes:UP000224567};
RA Kim S., Park J., Yeom S.-I., Kim Y.-M., Seo E., Kim K.-T., Kim M.-S.,
RA Lee J.M., Cheong K., Shin H.-S., Kim S.-B., Han K., Lee J., Park M.,
RA Lee H.-A., Lee H.-Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E.,
RA Jeon J., Kim H., Choi G., Song H., Lee J., Lee S.-C., Kwon J.-K.,
RA Lee H.-Y., Koo N., Hong Y., Kim R.W., Kang W.-H., Huh J.H., Kang B.-C.,
RA Yang T.-J., Lee Y.-H., Bennetzen J.L., Choi D.;
RT "Multiple reference genome sequences of hot pepper reveal the massive
RT evolution of plant disease resistance genes by retroduplication.";
RL J. Anim. Genet. bioRxivorg:115410-115410(2017).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT52300.1}.
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DR EMBL; MLFT02000003; PHT52300.1; -; Genomic_DNA.
DR Proteomes; UP000224567; Chromosome 3.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000224567}.
FT DOMAIN 202..443
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 1207..1294
FT /note="Retrotransposon gag"
FT /evidence="ECO:0000259|Pfam:PF03732"
SQ SEQUENCE 1438 AA; 163974 MW; 8011C2AA9518F8DC CRC64;
MVVWCIKAPA KDRTTRPYHM QLYLEFCKLL FYPFIPEIPF ELYLIITEQI WKPGEKILQI
SVKTIEFGLR EAMIAEDEPQ RGKAHEQLSD SVQQDIITKA NVNIVDMAHA NVASLLRTIE
SLLSSNSPMR SVSCDHREDF SALHEKISSL EVFLKNFEKN NVSRELTDLE VQIKEVANIV
EQTIQLRVTE VVLKRHIMVG RDDQKERLLE DLTASYSGEP KVIPIVGMGG IGKTTLAKEV
YNNESVLRRF DVHAWATVSQ QHDRKEILLG LLRSTIKMED RVKTRGEAEL ADMLQKSLKR
KRYLIVLDDI WSCEVWDGVR QCFPTEDNAG SRILLTTRNN EVACYAGTEN LSMQMDFMDQ
DESWNLFESA AFSNEASSSE FETIGKKIAE KCHGLPLTIV VVAGLLKSKR EIEYWKSVAK
DVTSFVTNDP DKQCSRVLGL SYDHLTSDLK TCLLHFGIFP EDSEIPVKKL MRSWMAEGFL
KLENDLEGEA EKCLQDLVNR CLVLVCKKSR DETKIISCKV HDLIYELCLR EVERGSVFSM
NDIELEVSYS RGLYLSMRKM QPFKHVTGDL SYFGLYRALL TPVHRQLRDH DNNDLSKRTR
SIFSFHLKDS SFFLKSELIH FKLLKVLELR HIEIDNFPLQ ISSLIWLRYL SLVCNANFDV
PPEICRLWNL QTFIVQGSQT VITITITITF PEEIWGLMQL RHLKVKRVYL PNPPSVSADK
GSHTRFSNIQ TTSYLSSCCC TKEVISGIRN VKKLGFSGNN LSDSGLHSNL VYLQQLEILS
FIRCSCILLP VTSAKVFPAT LKKLKLESTY LDWSYMDIIA ELPNLEVLKL IDDACDGEEW
QQNVKGFTRL KLLFIHDNRL KCWKATNDNF PVLERLMLSK CSTLKEMPIE FAEIHSLQLI
ELTSCLPGLG KYAARIQKEQ QDLGNNPVDV RISNPFTEEV MANKDTELVV TNQIGSSGNE
NVGDNEEIRK LRRQIIEMHR AWANGLPPPP VPTDNLDYLS SLPPVSHAQL PIFVDMPQHA
SRSTPGQQYP TTSNIHFLTP QYKITTCSAL PAIHAFAAPL PSEAPAFNVN PTVVIPHSTS
NPILNIFSDQ HYAPKPTFKS TGPYVFPQPP EFPPNTEKPV MTEEQEEIAR KLRSLELTMK
NLQGLGGYKS VSYKDLCMFP GVHLPLGFKM PKFEKYDGHG DPIAHLRRYC NQLRGAGGKE
ELLMAYFGES LSGLASEWFV DQDIDKWNSW DDLANEFVQQ FQYNMELIPD EKSLTNMNKK
STETFREYAI RWREQAARVK PPMKESKIVE AFIQVQDETY YQHLLPALGK PFVEVPKMGE
MIEDGIKTGR IVSFATLKAT TQEIHKGLGS MGGRKNMEDA SAIAVGQQAW ARGPHHRYPR
AQTHVYAQAP TNHYQNPLYP VPPPPYQVYN AQPYVQPPSY PHWRAPTLSS HPPTPHTY
//
