ID A0A2G2X513_CAPBA Unreviewed; 1317 AA.
AC A0A2G2X513;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0000259|Pfam:PF00931};
GN ORFNames=CQW23_07038 {ECO:0000313|EMBL:PHT52576.1};
OS Capsicum baccatum (Peruvian pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=33114 {ECO:0000313|EMBL:PHT52576.1, ECO:0000313|Proteomes:UP000224567};
RN [1] {ECO:0000313|EMBL:PHT52576.1, ECO:0000313|Proteomes:UP000224567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PBC81 {ECO:0000313|Proteomes:UP000224567};
RC TISSUE=Leaf {ECO:0000313|EMBL:PHT52576.1};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
RN [2] {ECO:0000313|Proteomes:UP000224567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PBC81 {ECO:0000313|Proteomes:UP000224567};
RA Kim S., Park J., Yeom S.-I., Kim Y.-M., Seo E., Kim K.-T., Kim M.-S.,
RA Lee J.M., Cheong K., Shin H.-S., Kim S.-B., Han K., Lee J., Park M.,
RA Lee H.-A., Lee H.-Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E.,
RA Jeon J., Kim H., Choi G., Song H., Lee J., Lee S.-C., Kwon J.-K.,
RA Lee H.-Y., Koo N., Hong Y., Kim R.W., Kang W.-H., Huh J.H., Kang B.-C.,
RA Yang T.-J., Lee Y.-H., Bennetzen J.L., Choi D.;
RT "Multiple reference genome sequences of hot pepper reveal the massive
RT evolution of plant disease resistance genes by retroduplication.";
RL J. Anim. Genet. bioRxivorg:115410-115410(2017).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT52576.1}.
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DR EMBL; MLFT02000003; PHT52576.1; -; Genomic_DNA.
DR Proteomes; UP000224567; Chromosome 3.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 3.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000224567}.
FT DOMAIN 198..378
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 621..687
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 691..813
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1317 AA; 150901 MW; 23290CB927D734D4 CRC64;
MQNACLGEEW YPNVRVFTRL KFLLIKGNRL KHWKVTDDNF PALVLKECYN LKEIPIEFAE
IHTLQLIELS WCLPKLGESA ARIQKEQEDL GNNPVDVCIS HLRITGSRFF KGISNIWTRQ
KFGKSLQQFA KGIDRVRKES TKIQDKGKQA SKESTIQDFS SSANDNLNVK NNMVVRDDQM
KRLFKDLTIS YSDEPKHNRK EIFLGLLRST IKVDDTVETS GEAELADMLQ KSLKRKRYLI
VLDDIWSCEV WDGVRQCFPT DDNAGSRILL TTRNDEVACY AGVENLSLRM SFMDQDESWS
LFKSAAFASE ALPSEFETTG KQIAEKCHGL PLTIVVVAGL LKSKREIEDW ENVAKDVKSC
LTNDPDELCS RVLGLSYNHM TSNLKACLLH FGIFPEDSEI TAKKSMRSWM AEGFLNLEND
LEGEAEKCLQ ELVDRCRVLV YKTSLDGEKF ISCKLSGHNW NTIDMANASV ASLVRTIQSV
LISNSPALFN LICGHREKIK TLHEKVGSLE VFVKNFEKNN VSGEMTDLEV EVKEVARAAE
YTIQLRLTET VLGENKSQKK KARRRFRQSL QQVVEDMDRI WKESTKIQAK AKQASNESLV
HDFSSSANDI LNVNNNMVGR DDQKEHLLED LTGSYSCEPK VILIAGMGGI GKTTLAKEVF
NHESIIRRWA TVSQQHNIKE IFLNLLQSTI KMDDTVKTKV WDGVKRCFPT EDNAGSRILL
TTRSNEVACY AGTENLSMQM DFMDQDESWN LFKSVAFSSE ALPYEFETVG KQIADECHGL
PLTIVMVAGL LKSKRAIEDW EIVARDVTSF VTNNPDERYS EIPVKNLMIS WMAEGFLKLE
NDLEGEAEKC LQELVDRCLV LVFKKNLDGT KIRSCKVHDL IYDLCLREIQ WENIFIMNDI
VLGVSECGNL SMQKMQPYKR VTGDKIECHL YGLYRALLTP VHRQLRDHDN NVLLERTRSI
FSFHLEYSFS VLKSELMHFK LLKVLVLRHR EIDNFPLQIL SLIWLRYLSL QCSRNLNISP
EICRLWNLQT FIVQGLNGSV ITITFPEEIW GLMQLRHLKL PEFYLPNPPS VSADKGSHMG
FSNIQTFSYL HPRCFTNEVI MGIQNVKEIG IFGNEIRSNG LLNSLVHLQQ LETLSLIYCF
SRFLPASAKA FPATLKKLKL KRNYLRWSYM DIIAELPNLE VPNVTGFTRL KVLLIEDCFL
MYWKATDDNF PVLERLVLKK CRYLKEIPIE FAEIHTLQLI ELTSFLPELG ESAARIQQEQ
EDLGNNPVDV HISNDTWKLH ALKVPLCLRI RGWLRPKDLL DVVLPCIPAR GCFHILN
//
