ID A0A2G2XIC1_CAPBA Unreviewed; 1152 AA.
AC A0A2G2XIC1;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN ORFNames=CQW23_05730 {ECO:0000313|EMBL:PHT57244.1};
OS Capsicum baccatum (Peruvian pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=33114 {ECO:0000313|EMBL:PHT57244.1, ECO:0000313|Proteomes:UP000224567};
RN [1] {ECO:0000313|EMBL:PHT57244.1, ECO:0000313|Proteomes:UP000224567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PBC81 {ECO:0000313|Proteomes:UP000224567};
RC TISSUE=Leaf {ECO:0000313|EMBL:PHT57244.1};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
RN [2] {ECO:0000313|Proteomes:UP000224567}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PBC81 {ECO:0000313|Proteomes:UP000224567};
RA Kim S., Park J., Yeom S.-I., Kim Y.-M., Seo E., Kim K.-T., Kim M.-S.,
RA Lee J.M., Cheong K., Shin H.-S., Kim S.-B., Han K., Lee J., Park M.,
RA Lee H.-A., Lee H.-Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E.,
RA Jeon J., Kim H., Choi G., Song H., Lee J., Lee S.-C., Kwon J.-K.,
RA Lee H.-Y., Koo N., Hong Y., Kim R.W., Kang W.-H., Huh J.H., Kang B.-C.,
RA Yang T.-J., Lee Y.-H., Bennetzen J.L., Choi D.;
RT "Multiple reference genome sequences of hot pepper reveal the massive
RT evolution of plant disease resistance genes by retroduplication.";
RL J. Anim. Genet. bioRxivorg:115410-115410(2017).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT57244.1}.
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DR EMBL; MLFT02000002; PHT57244.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G2XIC1; -.
DR STRING; 33114.A0A2G2XIC1; -.
DR Proteomes; UP000224567; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10809; GH38N_AMII_GMII_SfManIII_like; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000224567};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT TRANSMEM 39..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 487..572
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 131865 MW; 10D30BC5E2DC8B1E CRC64;
MAFSSRRGGA GWAHSLLPTT KPSPRQPRKS RRRTAVRDFI FSNFFTIGLS LSLVVFIFIV
YSYGIPKPPL STHFPNARTR FPRIRKTSSR KSPGSDGVAG AVVDITTKGL YDKIEFRDED
GGAWKQGWKV NYKGNEWDTE KLKIFVVPHS HNDPGWKLTV EEYYDRQSKL ILDTLVETLP
KDSRRKFIWE EMSYLERWWR DATEEKKEAF TNLVRNGQLE IVGGGWVMND EANSHYFAII
EQITEGNMWL NETIGVIPKN SWSIDPFGYS PTMAYLLRRM GFENMLIQRT HYELKKELAL
YQNLEYVWRQ SWDAEERTDI FVHMMPFYSY DVPHTCGPEP AICCQFDFAR MYGFAYERCP
WGEHPVETIQ ENVKERALKL LDQYRKKSTL YRTNTLLVPL GDDFRYVSVD EAEAQFRNYQ
MLFDYINSNP GLNAEAKFGT LDDYFRTLRD EADRVNYSRP HEIGSGEIVG FPSLSGDFFT
YADRQQDYWS GYYVSRPFFK AVDRVLEHNL RSAEMLMAFL LGYCQKIQCE KFPTGFSHKL
TAARRNLALF QHHDGVTGTA KDHVVQDYGS RMHMALQDLQ IFISKAIEVL LGMRHEKNDQ
YPSQFEPAQS RSKYDAQPVV KALSARQGTV QTVVLFNPSE QTRNEVVMVT VERPDVTILD
SNWTCIKSQI SPELAHDKKR TLSRRHRVYW KASVPAMGLQ TYYVANGFAG CEKAIPAQLR
ILVSSGNFSC PAPYTCSKLD SNEASIQNEH LTLTFSTKFG LLQKVSHSDG RQNVIDEEID
MYSSSGGAYL FKPEGEAAPI VQAGGTMVIS EGHLVQEVYS YPMTAWDKSP ISHSTRIYNG
HSTIQEHIIE KEYHVELLGH EFNDKELIVR YKTDIGNKRI FYSDLNGFQM SRRETYDKIP
TQGNYYPIPS LAFMQGPNGH RFSVHTRQSL GVASLKDGWL EIMLDRRLVR DDGRGLGQGV
LDNRAMNVVF HILMEANVTA AANHTTGPHP RNPSLLSHLV GAHLNYPLHV FIAKKSEAIS
VQPPPRSFSP LAASLPCDLH IVNFKVPRPL KYTQQLEEPR FALVFQRRHW DSSYCRKGRS
ECSSVSDVPV NLFDMFKSLA VSNVKATSLN LLHDDIEMLG YSGHFGDGAH DGHVLISPME
IQAYKLELKF HS
//
