ID A0A2G2XZW2_CAPAN Unreviewed; 176 AA.
AC A0A2G2XZW2;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Nicotianamine synthase {ECO:0000256|ARBA:ARBA00012675, ECO:0000256|RuleBase:RU368095};
DE EC=2.5.1.43 {ECO:0000256|ARBA:ARBA00012675, ECO:0000256|RuleBase:RU368095};
GN ORFNames=T459_33064 {ECO:0000313|EMBL:PHT63044.1};
OS Capsicum annuum (Capsicum pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=4072 {ECO:0000313|EMBL:PHT63044.1, ECO:0000313|Proteomes:UP000222542};
RN [1] {ECO:0000313|EMBL:PHT63044.1, ECO:0000313|Proteomes:UP000222542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. CM334 {ECO:0000313|Proteomes:UP000222542};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
CC -!- FUNCTION: Synthesizes nicotianamine, a polyamine which serves as a
CC sensor for the physiological iron status within the plant, and/or might
CC be involved in the transport of iron. {ECO:0000256|RuleBase:RU368095}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-
CC methyl-5'-thioadenosine; Xref=Rhea:RHEA:16481, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17509, ChEBI:CHEBI:58249, ChEBI:CHEBI:59789; EC=2.5.1.43;
CC Evidence={ECO:0000256|ARBA:ARBA00000566,
CC ECO:0000256|RuleBase:RU368095};
CC -!- SIMILARITY: Belongs to the nicotianamine synthase (NAS)-like family.
CC {ECO:0000256|ARBA:ARBA00007009, ECO:0000256|RuleBase:RU368095}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT63044.1}.
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DR EMBL; AYRZ02000046; PHT63044.1; -; Genomic_DNA.
DR STRING; 4072.A0A2G2XZW2; -.
DR EnsemblPlants; PHT63044; PHT63044; T459_33064.
DR Gramene; PHT63044; PHT63044; T459_33064.
DR OMA; AGANTMX; -.
DR Proteomes; UP000222542; Unassembled WGS sequence.
DR GO; GO:0030410; F:nicotianamine synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030418; P:nicotianamine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004298; Nicotian_synth.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR32266; NICOTIANAMINE SYNTHASE 3; 1.
DR PANTHER; PTHR32266:SF12; NICOTIANAMINE SYNTHASE 3; 1.
DR Pfam; PF03059; NAS; 1.
DR PROSITE; PS51142; NAS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000222542};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|RuleBase:RU368095};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU368095}.
SQ SEQUENCE 176 AA; 19811 MW; C114DFD645481667 CRC64;
MVCPNSNPVV QKVCELYEQI SRLENLSPCK DVNMLFTDLV HTCMPPNPID VSKLCQKIQE
IRSHLIKLCG EAEGLLESHF STILATYENP LDHLDIFPYF DNYIKLSLLE YNILTKNTIK
IPNKIAFVGS GPLPFTSIVL ATKHLTTTYF HNYDIDAGAN TMXXXXXXXI LTCPKG
//
