ID A0A2G2Z715_CAPAN Unreviewed; 1087 AA.
AC A0A2G2Z715;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=T459_15844 {ECO:0000313|EMBL:PHT77792.1};
OS Capsicum annuum (Capsicum pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=4072 {ECO:0000313|EMBL:PHT77792.1, ECO:0000313|Proteomes:UP000222542};
RN [1] {ECO:0000313|EMBL:PHT77792.1, ECO:0000313|Proteomes:UP000222542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. CM334 {ECO:0000313|Proteomes:UP000222542};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT77792.1}.
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DR EMBL; AYRZ02000006; PHT77792.1; -; Genomic_DNA.
DR EnsemblPlants; PHT77792; PHT77792; T459_15844.
DR Gramene; PHT77792; PHT77792; T459_15844.
DR OMA; EIQPINI; -.
DR Proteomes; UP000222542; Chromosome 6.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR015063; USP8_dimer.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF08969; USP8_dimer; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000222542}.
FT DOMAIN 307..399
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 401..484
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 959..1045
FT /note="USP8 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF08969"
FT REGION 1062..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1087 AA; 125642 MW; 337CA1BBE4477478 CRC64;
MVALSTRLFN VSPQFQLMTE RVGLFFWNSR TYGDSQLFKL AHLLMKIIPI ELEVMHICFT
SLKASPSAEV ERFIKQILET SPDIIREYLI HLQEQMITVT TPSNSGARKI HVMIEFLLIV
LTDMPKDFIH HDKLFDPMER IGTLIREEDL KYVYLKAPDA FQWSFPMSDG PLFLHLLHKH
LNDLQDSNAY SIALIKEDIE LVKEALKFIR SCIVNLEEGL YKDLWARVLD VAYEAKDVID
SIIIRDNGLL HFVFSLPITI KKISLIKEDV SKLLEKIPKN KSLIVVNAPN NPVERKSLTT
GFKEETNWLI SKLTRGPKDV DVISITGMPG SGKTTLAYKV YNDESVCSHL DIRAWFTVDQ
EYDEKKLLVY LFNQVTGSDL KSSEDIDVAD KLRKQLYGKS PEESWELLEK RAIGEQIFPD
ELLEVGKENV HNCKGVPLVV DLIAGVIAGK ENKKSVWLEV QNNLNSFILN SEVDVMKVIE
LSYDHLPLQL KPCFLYLXVM KVIELSYDHL PLQLKPCFLY LSSYLKDTAV DRDVLKMYWR
AEGLVEQTEM KSLEEVMEIY LAMSISSSLV IAFNKMGDLP SCQIHDLVHD FCCIKAKEET
LFEKISSSDP SSSSSDLMPQ MVNIDYNKEK FELSNVVLFS SKRKRHSGKH LYSLKITGHK
MVDSLSDACH LRDLRPLRVL VMRDSFMMVK DSLLNEICML NHLRFLAIET EVKSLPSSFS
NLWNLETLFV DKKGSTLVLL PRIRDLVKLR VLSIDACYFF DLDTDESILI AEDSKLEKLR
VFETLVLSYS EEIEDIFKRF PNLQRLRFNL KESWDYSTER YWFPKFDFLT ELEHLTVDFK
SSNSNDSEAS VATNRSWDFH FPSNLKTLLL LPNLEELFLR RTIIQGEEWN MREEDTFENL
KYLNLTEVTL AKWEVGEESF PVIEKLVLRK CHMLEEIPPS FGEICSLKII KLVKSPQLED
FAKKIKQYVE DMGGDELQAN IHRGEKNIID LYIILLRYSS LVTETIPSHR DYQALHPKER
ALSKTHLLAV LDELEGLKPE FQRQFQGIGE VQVTAQHYQL NNKENHRYRP VGNSPSTSNK
ASSDYDN
//
