ID A0A2G2Z7G7_CAPAN Unreviewed; 1140 AA.
AC A0A2G2Z7G7;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0000259|Pfam:PF00931};
GN ORFNames=T459_15903 {ECO:0000313|EMBL:PHT77851.1};
OS Capsicum annuum (Capsicum pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=4072 {ECO:0000313|EMBL:PHT77851.1, ECO:0000313|Proteomes:UP000222542};
RN [1] {ECO:0000313|EMBL:PHT77851.1, ECO:0000313|Proteomes:UP000222542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. CM334 {ECO:0000313|Proteomes:UP000222542};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT77851.1}.
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DR EMBL; AYRZ02000006; PHT77851.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G2Z7G7; -.
DR EnsemblPlants; PHT77851; PHT77851; T459_15903.
DR Gramene; PHT77851; PHT77851; T459_15903.
DR Proteomes; UP000222542; Chromosome 6.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022667};
KW Reference proteome {ECO:0000313|Proteomes:UP000222542}.
FT DOMAIN 417..535
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 214..262
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 12..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1140 AA; 132103 MW; F775F7C8ECB22AA0 CRC64;
MKAVLTHNDL NKALDGKSKK PDSMNDEEWE ELDEKEISAI QLSLSKEAYD LLNFPTIGQL
PRTKLEGIVS RETNNVRQLQ QTEYAIPQKV CCNIRDFHGL ILNGYIEREI VEYVLPQLQR
MAEKVGIFLW DDLTSEDSKV FKLAHLLMKL IPIKLEYLIH LQEHMVTFIT TTTPGAQNIH
VMIEFLLIIL TDVPKDFIHH DKLFDLLACV GALIREVSTL VRNLEEKSRN EESNDETSRA
TLDLLEEKIE LLKEDLKNDY LKAPDSFQCF PMSDGSLFMH LLLIHLNDLL DSNSYSIALI
KDEITLMKET LEFIRLFFVN VEQGLYKDPW ARVLDVAYEA KDVIDSIIVR ANGLLHLIFS
LPITMKKIKL IKEDASQLSE KIPKNKSLIA VNSPKNPVER KSLTTSKIIV GFKEETNWLI
SKLTSGPKDL DVISITGMPG SGKTTLAYKV YNDESVCSHF DLRAWCTVNQ DYEEKKLLMK
LFNQVTGSDL KFSEDIDVAD ELRRKLHRKR YLIVLDDVWD IDTWDDLTRP FHGKSNTDPL
NLRSLRPEER REKTTSVWHD VRNNLNSFIF GSEVDVMKVI ELSYGHLPLQ LKPCFLYLAR
YPKDREIYRG DDPTCQLHDL VHDFCLIKAK EEKLFEQQIS SSDPSFSSSD LMPRMVNISY
NKEQFGLNNF ILFISKMKKH SCKSLCSLEI TGDEMEDRLS DSCHLRDLRL LRVLILFHSF
MMVKDSLLNE ICMLNHLRFL RIGTEVKSLP SSFSNLWNLE TLLVDNKLST LVLLPRIWAI
VKLRVLCTHA CSFFDLDIDE PILIVEDLKL ENLRICECCA LMLSYSKETE DFFIRFPNLQ
RLVFDLKESW DYSPELYWFP NLDFLHELET LEVVFESSIT NDNGPSAATN WTWDFHFPSN
LKILSLLNFP LTSDSLSIIA RLPNLEHLFL TRTIIKWGEW NMREEDTLEN LKFLMLDNVT
LAKWEFGEES FPMLEKLQLW GCHMLEEIPS NFGDIGSLKI IQLVESPQLE NSEIKEYVED
IMGWDLEAQF TPPSWRAAAM PSTGSFLLPN ASDFNCNNVT EEVQCNKKWD TRSAKSLNCD
AQHGYRHPPL MSTRLLFLCQ EYSRYPLLIL TIRSIESFLG GTFKSIKYRI DELDEEESVI
//
