ID A0A2G2ZB13_CAPAN Unreviewed; 1521 AA.
AC A0A2G2ZB13;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=T459_17252 {ECO:0000313|EMBL:PHT79200.1};
OS Capsicum annuum (Capsicum pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=4072 {ECO:0000313|EMBL:PHT79200.1, ECO:0000313|Proteomes:UP000222542};
RN [1] {ECO:0000313|EMBL:PHT79200.1, ECO:0000313|Proteomes:UP000222542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. CM334 {ECO:0000313|Proteomes:UP000222542};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT79200.1}.
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DR EMBL; AYRZ02000006; PHT79200.1; -; Genomic_DNA.
DR EnsemblPlants; PHT79200; PHT79200; T459_17252.
DR Gramene; PHT79200; PHT79200; T459_17252.
DR OMA; RRHAIYN; -.
DR Proteomes; UP000222542; Chromosome 6.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF00931; NB-ARC; 3.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000222542}.
FT DOMAIN 250..330
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 738..843
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 844..897
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 1442..1476
FT /note="Integrase zinc-binding"
FT /evidence="ECO:0000259|Pfam:PF17921"
FT REGION 1489..1521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1521 AA; 174205 MW; FECCA6D03C5F6D70 CRC64;
MKWHVERLRQ LLPKLIPQNP TFPVQTPFAE SFPKEEVGCP DPYQGKEEIE TSLVLDSELI
ESEALASSKS VREIDHALFR FNILFEDDIN TPNEPSGENY GIACLEGYSR YANPLWYDNI
PPKDENLFLE DDSTLMGKEC VVSKMSTLGS TLGVHDDQFT LKYSSLLEHV NEVLKNSQVS
DGVYRIDLDN AHDSLNILCG KSIAISFVHR DHVESESGLQ KGPRILKIRG LIWSVLSCFR
CLSRISYAGT ENLSLHMDFM DQDDSWNLFK SAAFANEALP SEYENIGKQI VDECHGLPLT
IVVVAGLLKF KRAIEDWKSV AKDVKSFVTN DPDERCSHVL GLIYNHLTSD LKTCLLYFGI
FLEDTKIPVH LVRLWMDDGF LNLQNELEGE AEKCLQDLID RCLVLFSEKS LDETKISTCY
VHDLIYDLFL REVQRGNIFT TNDIVFDNSD ANHDRSKCQS LSRHKLHPFK SFTGDEIHDF
PYGFYSTRQL RDHSNNDPLK RTHSIRISGG YFSTLILKSV LIHFKLLKLL DLSHMRIVSF
PLQIVSLIWL RYLALHCAEL PNLEVLELMD YACCGKEWHP IVRGFTRLKL LLIEENDLRY
WKATDNNFPV LECLVLKECS YLKEMPIEFA DIHSLQLIIL TSCLPELGES AARIQKEQEE
IGNNPVDVRI SNQGHNWNTI DMAYASVASL MRTIQSVLIS NSPTLFNLIC GHREEIVTLH
EKVSSLGVFL KNFEKNNVSG EMMDFEVEEI LVSLLHSTKG DTFDMVDKAK IADMLQKSLK
SKRYLIVLDD IWSCEVWDDV RRCFPTENNT GSRILLTTRN NEVACYAGTE NLSLQMDFMD
QDEKKCHGLP LTIVVVAGLL KSKRTIEDWE SVAKDVKSFV TNYPDERCSY VLGLSYNNLT
SNLKSCLLYF GIFREDTEIP VKNLMRLWMA EGFLNLENDL EGEAMKCLQD LIDRCLVLVG
KKSLDETKIR SCKVHDLVYD LCLRELQRGT IFIRNDIVFE KSDVNPLPSK CQFLSSRNMK
PFKRWTYDEI HGCHYGLYKA LLTPVHYLIH FKLLKVLDLR PIEIDRFPLE ILSLIWLSYL
AFSYPRNFDI PSEICKLWNL QTSGIQNIKK LGIRGDKVDY ESLRESGLLN NLVHLQQLET
LSLQLYFRKL SVISSAKVFP ETLKKLKLYG TNLSWSYLDI ISELPNLEVL KLMPNACYGG
EWYPIVRGFN RLKLLLVKNS DLQFWKATND NFPILERLML THCLLLFEIP IEFADIHSLQ
LIELRDCLPE LGESAARIQQ EQEELGNNPV DVRMLRFLNA LSQIQSVAAD SVYYYSVLSA
GTSHVLVYGP LGPYAPHVVV YNSSRMSKFM SGVSESMLKE CKTVILIKEM DIPRLMVHSQ
QIEGAKNKEK ERLNQKKVKF QWLDSCEKSL QELKTRLTSA PVLTLLDGSG GFVVYCDASR
VGATKMYREL REIYWWSGMK RDIAEFVAKS SSCRQVALPY KSDISRSIWN PPLTRRGSPQ
PECPARVGVS ESDTPQGSRP A
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