ID A0A2G3AC21_CAPAN Unreviewed; 1221 AA.
AC A0A2G3AC21;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=T459_06836 {ECO:0000313|EMBL:PHT91723.1};
OS Capsicum annuum (Capsicum pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=4072 {ECO:0000313|EMBL:PHT91723.1, ECO:0000313|Proteomes:UP000222542};
RN [1] {ECO:0000313|EMBL:PHT91723.1, ECO:0000313|Proteomes:UP000222542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. CM334 {ECO:0000313|Proteomes:UP000222542};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT91723.1}.
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DR EMBL; AYRZ02000002; PHT91723.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G3AC21; -.
DR STRING; 4072.A0A2G3AC21; -.
DR EnsemblPlants; PHT91723; PHT91723; T459_06836.
DR Gramene; PHT91723; PHT91723; T459_06836.
DR OMA; KHIMQTP; -.
DR Proteomes; UP000222542; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR CDD; cd18023; DEXHc_HFM1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:PHT91723.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000222542}.
FT DOMAIN 34..229
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 259..463
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1221 AA; 138156 MW; 2D8B1B0FB0F34345 CRC64;
MDGYALKSVS DLPPVFRSTF SFRYFNSLQS ECFPACFLSD MNMVISAPTG SGKTVLFELC
ILRLLSRFIS GEGKFIHTKG ALKTIYVAPS KALVQEKLRN WNQKLGSWGI NCLELTGDNE
SYKITDIQVA DVILTTPEKF DAVTRYRIND GGLSFFGDIA LVLIDEVHLL NDPRGAALEA
ILSRIKMLSR KPELKSSALA NVRFLAVSAT IPNIDDLAEW LMVPMQGVKR FGEEMRPVKL
TTKVFGYTPA KNDFLFEKRL QNYVFDILMQ HSRGKSALVF CSTRKGAQEA ARQLSQTAMT
YGHSNPFIKS REQQERLREA SLSCSDKQMQ SYILYGVGYH NGGLSMNDRN LIEGLFLNGD
VQVLCTTNTL AHGINLPAHT VVIKSTQYFN KEKGIYMEYD RSTILQACFS SLGAGRPPFD
DTGVVIIMTR KETVHLYENL LSGCELVESQ LLPCVTEHLT AEIVQLTVSD ITGAIEWMKC
SYLYVRMKKN PEKYGVRKGL IGDRLERHMQ DICVQNVNEL SRYQLIWTDE DGFLLKPLEP
GKLMTKYYLK FDTMKHIMQA PGNCSIEDAL QIVCRAEELG WIQLRRNEKK LLNDINIDKD
NRLRFHILGD KAKRKKRVQT REEKIFVLAN DCLTGDPFIH DLSLSQDMNA VCANGYRIAK
CMKEYFLYRK NYRGALSSAL LTKSLYKKVW DDSPYLLKQL PGIGMVTAKA LHSMGVKSFS
SLSDADPRKI EMVTGRKYPF GNHIKESLLS LPPEVQMRVE ETEGQRQGRS KVMVTLIRLS
QPVQTTERHY ADMVVAVEED NLVLFHEKIS PYSKTVMVPS PQQGKLTVKA DLIFNEFIGV
DLHQKLVLIK EINLNFVMKY RTKQLSSFQE NDGCIIEDTE NTVQASCQVS HRLTEVDRIS
DMPSFKLIDE DLDEVIPAST VEDDECKIID EKTIFDHIRE KAKNLPALTS LKGTCSPSLE
TLNLIRKRTR EKQLLVENAA GVSDEVRRTK VPCHRVVVQS AEYIDLEANR PFSNKDQRPY
SHHASNAIYL AGETGELFFE TGSVPSETMA EETIFKYNPI DSNNFHSFEN VKNTEHKLLS
MANETCIIHQ PEHNSAIFGF QETIPTKVVE NAAVIMDLEP MKTKANAIKL IEEVEDLTLY
GYTPGTSEKT DLSLETSRKD AEGKSRLLSS ADDYVIRNKV GNPLRSPNFQ EQQGTCSVQV
GEISQANPFL GFKSIFAFLF E
//
