ID   A0A2G3E4H5_9FIRM        Unreviewed;       480 AA.
AC   A0A2G3E4H5;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=[FeFe] hydrogenase H-cluster radical SAM maturase HydG {ECO:0000313|EMBL:PHU38101.1};
GN   Name=hydG {ECO:0000313|EMBL:PHU38101.1};
GN   ORFNames=CSX02_04290 {ECO:0000313|EMBL:PHU38101.1};
OS   Agathobacter ruminis.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Agathobacter.
OX   NCBI_TaxID=1712665 {ECO:0000313|EMBL:PHU38101.1, ECO:0000313|Proteomes:UP000224563};
RN   [1] {ECO:0000313|EMBL:PHU38101.1, ECO:0000313|Proteomes:UP000224563}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JK623 {ECO:0000313|EMBL:PHU38101.1,
RC   ECO:0000313|Proteomes:UP000224563};
RA   Sheridan P.O., Walker A.W., Duncan S.H., Scott K.P., Toole P.W.O., Luis P.,
RA   Flint H.J.;
RT   "Resolving the taxonomy of Roseburia spp., Eubacterium rectale and
RT   Agathobacter spp. through phylogenomic analysis.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PHU38101.1, ECO:0000313|Proteomes:UP000224563}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JK623 {ECO:0000313|EMBL:PHU38101.1,
RC   ECO:0000313|Proteomes:UP000224563};
RA   Banno H., Chua N.-H.;
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PHU38101.1}.
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DR   EMBL; PDYG01000015; PHU38101.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G3E4H5; -.
DR   Proteomes; UP000224563; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0044271; P:cellular nitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0042364; P:water-soluble vitamin biosynthetic process; IEA:UniProt.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR010722; BATS_dom.
DR   InterPro; IPR024007; FeFe-hyd_mat_HydG.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR   NCBIfam; TIGR03955; rSAM_HydG; 1.
DR   PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR   PANTHER; PTHR43583:SF2; BIOTIN AND THIAMIN SYNTHESIS ASSOCIATED DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF06968; BATS; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDG01060; BATS_domain_containing; 1.
DR   SFLD; SFLDF00319; Fe_hydrogenase_maturase_(HydG; 1.
DR   SMART; SM00876; BATS; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000224563};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          283..390
FT                   /note="Biotin and thiamin synthesis-associated"
FT                   /evidence="ECO:0000259|SMART:SM00876"
SQ   SEQUENCE   480 AA;  54740 MW;  1D90F12B6E319EEF CRC64;
     MYNVKSLKAE EFIDNQEILD TIEYAEANKY NFEFIEELLE KARPLKTAEG CVCRGLTHRE
     ASVLLACDEP KYIEKMYQVA QEIKDAFYGN RIVLFAPLYL SNYCINGCVY CPYHAKNKHI
     ARKKLTQEEV KAEVIALQDM GHKRLAIEAG EDPVNNPIEY ILECINTIYS IHHKNGDIRR
     VNVNIAATTV ENYRKLKEAG IGTYILFQET YNKKSYEELH PTGPKHDYAY HTEAMDRAME
     GGIDDVGLGV LFGLESYRYE FAGLLMHAEH LEAVHGVGPH TISVPRVKHA DDIDPEAFDN
     SIPDEIFTKI AACIRIAVPY TGMIISTRES EEVRRKMLQV GISQVSGGSR TSVGGYTQEE
     RPHDTEQFDV SDQRTLDEVV KWLMETGHIP SFCTACYRAG RTGDRFMSLC KTGQIINCCH
     PNALMTLTEY LVDYASDETK EVGYKMIEEE LRKIPKENVR KTAAENIEAI KHSDRRDFRF
//