ID A0A2G3J8L7_9NEIS Unreviewed; 559 AA.
AC A0A2G3J8L7;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=CSQ88_15145 {ECO:0000313|EMBL:PHV00885.1};
OS Iodobacter sp. BJB302.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC Chitinibacteraceae; Iodobacter.
OX NCBI_TaxID=1506510 {ECO:0000313|EMBL:PHV00885.1, ECO:0000313|Proteomes:UP000224670};
RN [1] {ECO:0000313|EMBL:PHV00885.1, ECO:0000313|Proteomes:UP000224670}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BJB302 {ECO:0000313|EMBL:PHV00885.1,
RC ECO:0000313|Proteomes:UP000224670};
RA Jude B.A., Perron G.P., O'Brien K., Doing G., Bettina A.M.;
RT "Draft genomes of phenotypically distinct violacein producing isolates
RT cultured from the Hudson Valley Watershed.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHV00885.1}.
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DR EMBL; PDZG01000048; PHV00885.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G3J8L7; -.
DR REBASE; 245688; M.Isp302ORF15145P.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000224670; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:PHV00885.1};
KW Hydrolase {ECO:0000313|EMBL:PHV00885.1};
KW Nuclease {ECO:0000313|EMBL:PHV00885.1}.
FT DOMAIN 5..148
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 161..435
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 559 AA; 61901 MW; 6152B1A6FE28292E CRC64;
MLQDIQKTLW SAADKLRANV DAAEYKHIAL GMIFLKFISD SFSARRAELT RRFADENDDY
FLHDSDDELL AEELEDRDYY KEVNVFWVPE GARWEALRAN AKQADIGKRI DDALAILEQE
NPSLKGILDK RYARAPLPDG KLGELVDLIS TIGFGEDQGK ARDILGQVYE YFLGQFACAE
GKKGGQFYTP QSIVKTLVAV LDPHQGKVYD PCCGSGGMFV QSEKFIEAHG GQLGDVSIYG
QESNPTTWRL AAMNLAIRGI DFNLGREPGD TFTKNQHPDL RADYILANPP FNISDWWHGS
LEGDSRWVYG TPPQGNANYA WLQHMLYHLK SDGRAGIVLA NGSMSSSQNS EGDIRRAMVD
ADVVEVMIAL PGQLFFNTQI PACLWFLAKN KTTRQGEVLF IDARKLGKMI SRVQCELDDE
AITRIANLVK AWRGSAGKIP LNPPLPKGEA KTITLIQATA SVPPFEKGGP GGISAPDETI
TEYQDIPGFC RSVKLAEIAE HGHVLTPGRY VGAEEVEDND EDFATKMTAL TEKLGEQMAK
GAELDQLIRQ KLGGLGYEF
//
