ID A0A2G4T2V2_RHIZD Unreviewed; 1230 AA.
AC A0A2G4T2V2;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=DUF221-domain-containing protein {ECO:0000313|EMBL:PHZ15350.1};
GN ORFNames=RHIMIDRAFT_311416 {ECO:0000313|EMBL:PHZ15350.1};
OS Rhizopus microsporus ATCC 52813.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=1340429 {ECO:0000313|EMBL:PHZ15350.1, ECO:0000313|Proteomes:UP000242254};
RN [1] {ECO:0000313|EMBL:PHZ15350.1, ECO:0000313|Proteomes:UP000242254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 52813 {ECO:0000313|EMBL:PHZ15350.1,
RC ECO:0000313|Proteomes:UP000242254};
RX PubMed=27956601; DOI=10.1073/pnas.1615148113;
RA Lastovetsky O.A., Gaspar M.L., Mondo S.J., LaButti K.M., Sandor L.,
RA Grigoriev I.V., Henry S.A., Pawlowska T.E.;
RT "Lipid metabolic changes in an early divergent fungus govern the
RT establishment of a mutualistic symbiosis with endobacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:15102-15107(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KZ303844; PHZ15350.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G4T2V2; -.
DR STRING; 1340429.A0A2G4T2V2; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000242254; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 2.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242254};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 88..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..233
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 255..495
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 507..590
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 595..797
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 351..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..865
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1018
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1061
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1230 AA; 138477 MW; A3820217C32848A2 CRC64;
MSLTASVTGP SPTSFIPSTT SSIYSIPTSL SSVNGSSIIT SSPTVFTSTN NTIPTSTITT
ATSTTTPGSI FPGGEKFFNT QNPSKPSIQF GICAVAGLVF FIAFCFLRVR LPVMFAPRKN
MKRHKPPELS NSFFGWIIPV LKASTEEMLL NVGLDAVLML HFLVMAMKIF GLCSIFGVIV
LIPISATAKN NEKSMSDIEK ISITHTEDGD LRLIAFLVFT YFVTIVTLYY LTQSYYNYVY
LHAKYMLNQS KQMVSRSVII TGIPERLRSD QALAEYYENL GIGPVESCYV VRTVHQLDKL
IKQRASALTK LEKAYAKYWG NPCRIPGYDP DIILDDVEMY KKVLDLAEKR NDSSSSSSDS
EVEDENGNKQ KKKPFALRLT KKNTWKRAVN TTFFKGLIDP LEQEKRSKRP TVRTGFLGLF
GQKIDAIEYY TVLFDNLDKM VAEKRRSPHY EMTNVAFVTF EHMSSAVIAS QIAIHPEPFA
CRTILAYEPR DVLWSSVAIR GRERIIREII VWAITIALVI FWFVPVTILS SLLSLETLKR
VIPKLAKAIE GNEALKGFVS SFVTTVALNI VTSVLPLIFD GRVITKTQAQ QTNKMIIIAL
GYYQGLRSRS AIAESTFSKY FFFLVFFTLI TFTLANASMQ TVIDFANNPT SIPERLADTL
PNIAPFFINY VILQGFLLMP MNLLLLGALI VRGFYHAFIC KTPRDHAENR APWSFNYGTG
YPVPLLVFII VLEYSCISPI IMVFGAIYFC FTYVVYKYQF LYVYFRPYEA AGRLWIMTVP
RIIFGLVLFQ LTMTGYFVLR KFIALGATCA PLIAITILYK FILDRAFLKN ARNLPMQLLR
DNMQKLPDVV DPSDDDDDDD DDDDNYTQQQ QLKEADHSKN KNNDTTGTNS TEKVDREKQM
VRNKWKTAAL SAVQLRVKPK EEEQTSPEAS AVSIVRPRHR KVVLDEDDYE AVPDKLTDYR
QPPMQLNPGL LDTGLKRYGN PWIVGILPQL WLPMKEPDKA HKEGKAQSKR KRASDAFNRR
SEGGGTLAQH LAEVLRRMEM EAKRKEKKPD EKNEDDNKSS SGQDNQQRTK IAQETAQMTA
ASLAGHSPNN KTSALRTLFK MGALKKQGPK ATADAQIDEV AMSPVEPQHQ DPLEALEKGS
PVRHDSSESK ASAAKSVHAT YYHHPERRRH HSENTAHATP SRPEAHHSGV SSPAAFHDES
LTDDEHVEDH GEERLPTKRL SSVPLIDRSK
//
