ID A0A2G4T3E8_RHIZD Unreviewed; 514 AA.
AC A0A2G4T3E8;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:PHZ15535.1};
GN ORFNames=RHIMIDRAFT_272756 {ECO:0000313|EMBL:PHZ15535.1};
OS Rhizopus microsporus ATCC 52813.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=1340429 {ECO:0000313|EMBL:PHZ15535.1, ECO:0000313|Proteomes:UP000242254};
RN [1] {ECO:0000313|EMBL:PHZ15535.1, ECO:0000313|Proteomes:UP000242254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 52813 {ECO:0000313|EMBL:PHZ15535.1,
RC ECO:0000313|Proteomes:UP000242254};
RX PubMed=27956601; DOI=10.1073/pnas.1615148113;
RA Lastovetsky O.A., Gaspar M.L., Mondo S.J., LaButti K.M., Sandor L.,
RA Grigoriev I.V., Henry S.A., Pawlowska T.E.;
RT "Lipid metabolic changes in an early divergent fungus govern the
RT establishment of a mutualistic symbiosis with endobacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:15102-15107(2016).
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DR EMBL; KZ303844; PHZ15535.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G4T3E8; -.
DR STRING; 1340429.A0A2G4T3E8; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000242254; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000242254}.
FT DOMAIN 49..171
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 256..491
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 514 AA; 60116 MW; D10070449DBFEAD5 CRC64;
MTDCDIPYLL IGFKESTVSA ISTQTTKLYP NEQSSHILKD QLVRFILQRQ YHLSGVFKQD
VSNHYKETPV DIVQQVINDE ENDDIFLLVY RKFMTPKDLL QQLVKQFGEY DSPLTSEQER
ILSILHSWTS CYWNDFYCSA TRNTLQLFLE RIHDVESPLY ERIVALTSAE PPEVDRDASW
GVSDDGRNET LGTISEEGDI YLPMRRSKST QIKPSATNKE PTKRFSTPAI PLLISPGIKR
TLTKRRTLAS VLNTITVKDM AEQLTWIETE LYSKIQPRDF LRHIWRQRQD QPTPIAASIE
HFNFVSEWIA SMIVNQDQVE ERAFVYEYCL AIAVELEKLN NFNTLMAVLA GINNAAILRL
KETKHLVFER NKKLVEKFSR LESLMSSERS FYNYRCALKE RSKSFGIPYL GIHQQDLVSL
CEANKDHKTN GKIHWQKFRL IGQSINEVMT RFESMNGRIE PNPFILYFIG NELEILTEDE
RYEKSIRLEP RELHSSFTYN NHHHSSHRWL MLRT
//
