ID A0A2G4T4T5_RHIZD Unreviewed; 439 AA.
AC A0A2G4T4T5;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Endopeptidase S2P {ECO:0000256|ARBA:ARBA00032658};
GN ORFNames=RHIMIDRAFT_264959 {ECO:0000313|EMBL:PHZ16027.1};
OS Rhizopus microsporus ATCC 52813.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=1340429 {ECO:0000313|EMBL:PHZ16027.1, ECO:0000313|Proteomes:UP000242254};
RN [1] {ECO:0000313|EMBL:PHZ16027.1, ECO:0000313|Proteomes:UP000242254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 52813 {ECO:0000313|EMBL:PHZ16027.1,
RC ECO:0000313|Proteomes:UP000242254};
RX PubMed=27956601; DOI=10.1073/pnas.1615148113;
RA Lastovetsky O.A., Gaspar M.L., Mondo S.J., LaButti K.M., Sandor L.,
RA Grigoriev I.V., Henry S.A., Pawlowska T.E.;
RT "Lipid metabolic changes in an early divergent fungus govern the
RT establishment of a mutualistic symbiosis with endobacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:15102-15107(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KZ303843; PHZ16027.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G4T4T5; -.
DR STRING; 1340429.A0A2G4T4T5; -.
DR OrthoDB; 51250at2759; -.
DR Proteomes; UP000242254; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR001193; MBTPS2.
DR InterPro; IPR008915; Peptidase_M50.
DR PANTHER; PTHR13325:SF3; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE; 1.
DR PANTHER; PTHR13325; PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE; 1.
DR Pfam; PF02163; Peptidase_M50; 1.
DR PRINTS; PR01000; SREBPS2PTASE.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242254};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 128..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..388
FT /note="Peptidase M50"
FT /evidence="ECO:0000259|Pfam:PF02163"
SQ SEQUENCE 439 AA; 48417 MW; EFDE6B2566E5D901 CRC64;
MAVIVYAGLK ILSSLTRIAS VDQSQHVKRE LVEPNNGDEQ VFLPMIPGVT LPMSHIGYYL
LALTVCGLFH EAGHAMASFA EGVPIQSSGM FVMYLYPGAF VNIPDQQLQA LAPFRQLKII
CAGVWHNLVL YLFASLSLAG GLKLLLILIG WQSLEAQGGV SVVHIRTNSP LATHLPPATL
IYQLDDTPLT HNIEDWNAFL FKEDGRHALE QGFCVSKTHE NYGDKCCDID DTNPFGRSLN
ATISCFRSIE TALDKQCLST LPVLASKDIP RCKEASDCHG PEMSCVVPYT PSAAGQVVRI
YAQIPSWVES EEIDRRRIFI FEGELVDIWE SVKVSILSPR FWILPVSLPH ILELILRYIS
SFTIALALLN ILPAFKLDGE FALEQLLISF MQPTDASLVT TTRTYRATKQ VQDSIVKVTS
IVVGFVIVGS LVMGLLSVV
//
