ID   A0A2G5B248_COERN        Unreviewed;      1207 AA.
AC   A0A2G5B248;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=COEREDRAFT_83911 {ECO:0000313|EMBL:PIA12787.1};
OS   Coemansia reversa (strain ATCC 12441 / NRRL 1564).
OC   Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC   Kickxellomycetes; Kickxellales; Kickxellaceae; Coemansia.
OX   NCBI_TaxID=763665 {ECO:0000313|EMBL:PIA12787.1, ECO:0000313|Proteomes:UP000242474};
RN   [1] {ECO:0000313|EMBL:PIA12787.1, ECO:0000313|Proteomes:UP000242474}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 1564 {ECO:0000313|EMBL:PIA12787.1,
RC   ECO:0000313|Proteomes:UP000242474};
RX   PubMed=25977457; DOI=10.1093/gbe/evv090;
RA   Chang Y., Wang S., Sekimoto S., Aerts A.L., Choi C., Clum A., LaButti K.M.,
RA   Lindquist E.A., Yee Ngan C., Ohm R.A., Salamov A.A., Grigoriev I.V.,
RA   Spatafora J.W., Berbee M.L.;
RT   "Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell
RT   Walls of Algal Ancestors of Land Plants.";
RL   Genome Biol. Evol. 7:1590-1601(2015).
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DR   EMBL; KZ303570; PIA12787.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G5B248; -.
DR   STRING; 763665.A0A2G5B248; -.
DR   OrthoDB; 2788128at2759; -.
DR   Proteomes; UP000242474; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000242474}.
FT   DOMAIN          628..826
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          426..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          552..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          943..1031
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1074..1102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..299
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        943..983
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1086..1102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1207 AA;  130525 MW;  B5D162E64EDBB39D CRC64;
     MAKSKILVKA AAKPATGPDH PEPTARPRTA GGERGLLRRF RLGRILFGAG PDAGALVRRD
     GLQIFRTNSV HAPAPDLPHM PMSPSVESAQ TLAHSPRRGA MRVPTENYTD KRKSHYSMLS
     RRSSAPDVAE ITRRLSRHTE EDFTVPAEPS HAASSQHNLS ANAALLSLQT FKASAGQSLI
     SNRHHGSTSS SHHSSSADVE SAPNMTRATL VWKDPQPPSL ETQPASVTTT TSTSCSLSDS
     PALPSENVDE GKDYAAAYMM GPKTLVDNEQ NSRHSLNLNA TRSPPPQSRS PPPPASPKMV
     LPTTVNTSSP WPLPPLPTSP LPVSPTQLQE PFVNTTTIST TQLPQSAHVC AIPANNMGPI
     PLRRRNVSEQ GGLQQYRPKS LYERPSCRAL SALHREVGGS AAPQASSISS AKSFLMLIAS
     SNGNGAAGSA AKSNSLTNVT HEPQSYPPHS HPSTSTSIPA IATGFETAQD LERQLHSTTG
     DTSAASRVYN IERCAQEDTE SLACGVSPVS PDVSSSRSLR ARSKLAGVGI RRASTYMWNR
     SSVFVRTLSS TDELPGSSYP LQQPGSSGGV WESDMDTGST KTDDSASQNG AAALPTLALA
     YQINCAPKPP ALPPVVPLRP SKKSPAAMRL HAARELVMTE KNFVDNLFII KKVWMEPVFS
     SANSLKPIIP YQTARVIFYG VAALHAHASR FYREMDFALG SYERVQQPSE PVEDDGMRIG
     ALFRANDRHW SDFIAYVRNY GAAVGCLKQL QDYKPYLRYH EECMFQKRTS RQSLKDLLML
     PIQRITRYTL LLKNILKHTP AVHSDHIDLC RAVKNVTHFA TIVNECRRKQ EETYRTAEVL
     RSIGNCPPLY FSESRLFVAE YAVRELISRL PTRLMLFSDM LIVAQAPAHA MLDDTGSVGA
     EAVWTYYGSA LLDEVEVQNA DESTNTLITI LSLNRNSVSV NNFDSSSRRS LPFGSEQSAN
     ISSTSEPQNP VQNGSQCGST DTSDHADSHG RSSARNHGSG LQDASYAGAA LKKKKSKNRR
     GILNTGSRDS IPDHIAALSH STFPSPVPAP SHLERTQSRF YSTSPSPVTD VLVDRDVHPP
     PIQRPKTASG SHSTSSSTLV GHGGPLHSFD LAPPFRNQLQ DAFSNTISGT PVGVAGRTDA
     AALRSTHLTL VMQHATSIMR KQFVRALKDT TATFIHDTLS LGDSDAASIA THLVGDSSSE
     VLNLHPL
//