ID   A0A2G5C088_AQUCA        Unreviewed;       345 AA.
AC   A0A2G5C088;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=NAD(P)-binding domain-containing protein {ECO:0000259|Pfam:PF16363};
GN   ORFNames=AQUCO_108300001v1 {ECO:0000313|EMBL:PIA24690.1};
OS   Aquilegia coerulea (Rocky mountain columbine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC   Aquilegia.
OX   NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA24690.1, ECO:0000313|Proteomes:UP000230069};
RN   [1] {ECO:0000313|EMBL:PIA24690.1, ECO:0000313|Proteomes:UP000230069}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA   Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA   Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT   "WGS assembly of Aquilegia coerulea Goldsmith.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR   EMBL; KZ305544; PIA24690.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G5C088; -.
DR   STRING; 218851.A0A2G5C088; -.
DR   InParanoid; A0A2G5C088; -.
DR   OrthoDB; 5486426at2759; -.
DR   Proteomes; UP000230069; Unassembled WGS sequence.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:InterPro.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR   CDD; cd05246; dTDP_GD_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR01181; dTDP_gluc_dehyt; 1.
DR   PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR   PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230069}.
FT   DOMAIN          10..315
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
SQ   SEQUENCE   345 AA;  38596 MW;  1F6C30B9799186B2 CRC64;
     MASYTPKNIL ITGAAGFIAS HVANRLIRNH PDYKIVILDK LDYCSNLKNL LPSRSSPNFK
     FVKGDIGSAD LVNYLLIAES IDTIMHFAAQ THVDNSFGNS FEFTKNNIYG THVLLEACKV
     TGQIKRFIHV STDEVYGETD EDAVVGNHEA SQLLPTNPYS ATKAGAEMLV MAYGRSYGLP
     VITTRGNNVY GPNQFPEKLI PKFILLAMAG KPLPIHGDGS NVRSYLYCED VAEAFEVILH
     KGEVGHVYNI GTKKERRVID VAKDVCKLFS LDPGTVIKYV ENRPFNDQRY FLDDQKLANL
     GWSERTTWEE GLKKTMDWYT NNPDWWGDVS GALLPHPKML MMPGI
//