ID A0A2G5C2Z8_AQUCA Unreviewed; 1276 AA.
AC A0A2G5C2Z8;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=SEC7 domain-containing protein {ECO:0000259|PROSITE:PS50190};
GN ORFNames=AQUCO_10900008v1 {ECO:0000313|EMBL:PIA25664.1};
OS Aquilegia coerulea (Rocky mountain columbine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC Aquilegia.
OX NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA25664.1, ECO:0000313|Proteomes:UP000230069};
RN [1] {ECO:0000313|EMBL:PIA25664.1, ECO:0000313|Proteomes:UP000230069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT "WGS assembly of Aquilegia coerulea Goldsmith.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KZ305125; PIA25664.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5C2Z8; -.
DR Proteomes; UP000230069; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032817; Mon2_C.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF108; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16206; Mon2_C; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000230069}.
FT DOMAIN 115..302
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 68..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 143031 MW; BAD2DA7B8316EDD6 CRC64;
MTAMWMHPIF MRDICRTVNG LLKTALGPPP GSTTTLSPAQ DIAFRHESVK CLVGIIKSMG
AWMDQQLRIG DSHPPKGPED DLSTENPTTP RGEEGASFDY ELHSEANSEQ SDASTLEQRR
AFKIEFQKGI SLFNRKPSKG ISFLISSKKI GNSPEEVATF LRNTNGLNET MIGDYLGERE
DFSLKVMHAY VDSFNFERMD FGEAIRFFLR RFRLPGEAQK IDRIMEKFAE RYCKCNAGSF
KSADTAYVLA YSVILLNTDA HNSMVKDKMS KADFIRNNRG IDDGKDLPEE YLSDLYDQIV
KNEIKIKDNS IASQSKQANS LNKLLGLDGI LNLVTWKQAE EKPLGADGML IKNIQEQFRA
KTGKSESIYY GVTDAAILRF MVEVCWAPML AAFSMTLDQS DDKVAAFQCL LGFRYAVHVT
AVMGMQTQRD AFVTSVAKFT YLHNAADMKQ KNVDAMKAII SIAIEDGNYL QEAWEHILMC
LSRFEHLQLL GDGVPSDASF LNGHQSEAED KTQKSPGFPS IKKKGNALQN AAVMAVVRGG
SYDSTTRGVN TSGLVTPEQV NSFISNLNLL DQIGNFELSH IYAHSPRLNS EAIVAFVRAL
CKVSMVELQS PTDPRVFSLT KIVEIAHYNM NRIRLVWSRI WNVLSDFFVS VGLSENLSVA
IFVMDSLRQL AMKFLEREEL ANYNFQNEFL RPFVIVMKKS SSAEIRELIV RCVSQMVLSR
VNNVKSGWKS VFMVFTTAAA DERKNIVLLA FETMEKIVRD YFPYITETEN ATFTDCVKCL
ITFTNSRFNS DVSLNAIAFL RFCAFKLADG GLVRYEKSNE DDSYAEVIND DAADGHTFTD
KDDHIYFWVP LLTGLSKLTT DPRPAIRKSA LEVLFNILKD HGNLFSRAFW IAVFKSVVFP
IFDSNWDTRE TQDANNSRRL SGSTWTSETS SVASQCLVDL FVNFFDVVRS QLSGVVSVLT
SFIRSHGQSP ASIGVAALVR LAGDLGSKLS EDEWGVIFMA LKEAALSTLP AFLKVLRTMD
NIEVPDVAEA YGDSELFLDH GFTNDDMEDD SLQAAAYVIS RMKGHIAVQL LTVQVINELY
KTHQQLLSAA NIAILLEIFS SVASHAHELN SQTALQLKLQ KVCAVLEVSD PPIVHFENES
YQAYLSFLQI LVLNNTPLSK EMNIEPLLVE ICEMVVQIYL NCAGRQPSQQ RCDKQPILWI
LPLGSAKKEE LAARTSLVLL ALRVLCGLDR DSFRRYVTRF FPLLVDLVRS EHSSGEVQHV
LSDIFQSYIG PIVLNL
//
