ID A0A2G5CB57_AQUCA Unreviewed; 519 AA.
AC A0A2G5CB57;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=VHS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AQUCO_06900043v1 {ECO:0000313|EMBL:PIA28495.1};
OS Aquilegia coerulea (Rocky mountain columbine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC Aquilegia.
OX NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA28495.1, ECO:0000313|Proteomes:UP000230069};
RN [1] {ECO:0000313|EMBL:PIA28495.1, ECO:0000313|Proteomes:UP000230069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT "WGS assembly of Aquilegia coerulea Goldsmith.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the TOM1 family.
CC {ECO:0000256|ARBA:ARBA00007708}.
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DR EMBL; KZ305086; PIA28495.1; -; Genomic_DNA.
DR EMBL; KZ305086; PIA28496.1; -; Genomic_DNA.
DR STRING; 218851.A0A2G5CB57; -.
DR OrthoDB; 472902at2759; -.
DR Proteomes; UP000230069; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:InterPro.
DR CDD; cd14231; GAT_GGA-like_plant; 1.
DR CDD; cd03561; VHS; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR044836; TOL_plant.
DR InterPro; IPR014645; TOM1.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45898; TOM1-LIKE PROTEIN; 1.
DR PANTHER; PTHR45898:SF14; TOM1-LIKE PROTEIN 4; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036948; TOM1; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000230069};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 12..141
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 178..266
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT REGION 300..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 56791 MW; 12866A529EE7FD64 CRC64;
MANTAAACVE RATSDMLIGP DWAINIELCD IINMDPGQAK DALKILKKRL GSKNPKIQLL
ALFVLETLSK NCGENVYQQI VDRDILNEMV KVVKKKPDLN VREKILILID TWQEAFGGPG
GRYPQYYAAY HDLKTYGVEY PPRAENSVPL FTPPQTQPIV HPASTFEVDA VEASLRNDDS
GISLEEIQTA RGLADVLTEI LSALDPHSPE GVKQEVIVDL VDQCQSYQKR VMILVNNTTN
EELLCQGLTL NDDLQRVLRQ HDDIVKGGTV AARETPVAPL VNVNHEDDES EDDFAQLAHR
SSRDTVQGQG SKSANIKGEK LKVSPLLPPP PSSKKPDSRD AGLVDYLSGD AYRAERSEEV
PQVASHSDPL HSDSARVTPA VPSTIASSPP LYGNDSTSTP VFSGQPKYDE PLQTSKSTER
LPPAPWEVQS PVVIPPPPAK YNQRQQFFEQ QQQGFSGSSS PPASGSGYSY DGLVGQTQNL
SLNSEKNRAQ VSLTPKQSKS EDALFKDLVD FAKSKSPKS
//
