ID A0A2G5CBF7_AQUCA Unreviewed; 284 AA.
AC A0A2G5CBF7;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Nicotianamine synthase {ECO:0000256|RuleBase:RU368095};
DE EC=2.5.1.43 {ECO:0000256|RuleBase:RU368095};
GN ORFNames=AQUCO_06800046v1 {ECO:0000313|EMBL:PIA28612.1};
OS Aquilegia coerulea (Rocky mountain columbine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC Aquilegia.
OX NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA28612.1, ECO:0000313|Proteomes:UP000230069};
RN [1] {ECO:0000313|EMBL:PIA28612.1, ECO:0000313|Proteomes:UP000230069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT "WGS assembly of Aquilegia coerulea Goldsmith.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Synthesizes nicotianamine, a polyamine which serves as a
CC sensor for the physiological iron status within the plant, and/or might
CC be involved in the transport of iron. {ECO:0000256|RuleBase:RU368095}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-
CC methyl-5'-thioadenosine; Xref=Rhea:RHEA:16481, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17509, ChEBI:CHEBI:58249, ChEBI:CHEBI:59789; EC=2.5.1.43;
CC Evidence={ECO:0000256|RuleBase:RU368095};
CC -!- SIMILARITY: Belongs to the nicotianamine synthase (NAS)-like family.
CC {ECO:0000256|ARBA:ARBA00007009, ECO:0000256|RuleBase:RU368095}.
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DR EMBL; KZ305085; PIA28612.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5CBF7; -.
DR STRING; 218851.A0A2G5CBF7; -.
DR InParanoid; A0A2G5CBF7; -.
DR OrthoDB; 2718460at2759; -.
DR Proteomes; UP000230069; Unassembled WGS sequence.
DR GO; GO:0030410; F:nicotianamine synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030418; P:nicotianamine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004298; Nicotian_synth.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR32266:SF11; NICOTIANAMINE SYNTHASE; 1.
DR PANTHER; PTHR32266; NICOTIANAMINE SYNTHASE 3; 1.
DR Pfam; PF03059; NAS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51142; NAS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000230069};
KW S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU368095};
KW Transferase {ECO:0000256|RuleBase:RU368095}.
SQ SEQUENCE 284 AA; 31817 MW; ABB547C5FD85255D CRC64;
MASHQSPISE SHVPDELLIA RVMQIHSSIC KLESLRPSKQ VNSLFTQLVS LCTIPSSIDI
TDLPSEVQLM RESLIQLCGR AEGLLELKFA NFLINIPRPL DHLNVFPYYG NYVKLASLEY
SILYENGMAQ PKRVAFVGSG PMPLTSFVLA THHMQTTQFV NFDIDESANN VARQIIATDD
ELESRMKFET CDIMEVKERL GEFDCIFLAA LVGMNKADKV KILGHLKKYM KAGGTLLVRS
ANGARGFLYP VIEENDLVGF EILTIFHPTN EVINSVVLVR KPLF
//
