ID A0A2G5CCK1_AQUCA Unreviewed; 839 AA.
AC A0A2G5CCK1;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Glutamate receptor {ECO:0000256|PIRNR:PIRNR037090};
GN ORFNames=AQUCO_06800033v1 {ECO:0000313|EMBL:PIA28587.1};
OS Aquilegia coerulea (Rocky mountain columbine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC Aquilegia.
OX NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA28587.1, ECO:0000313|Proteomes:UP000230069};
RN [1] {ECO:0000313|EMBL:PIA28587.1, ECO:0000313|Proteomes:UP000230069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT "WGS assembly of Aquilegia coerulea Goldsmith.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. {ECO:0000256|PIRNR:PIRNR037090}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685, ECO:0000256|PIRNR:PIRNR037090}.
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DR EMBL; KZ305085; PIA28587.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5CCK1; -.
DR STRING; 218851.A0A2G5CCK1; -.
DR InParanoid; A0A2G5CCK1; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000230069; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd13686; GluR_Plant; 1.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR34836; OS06G0188250 PROTEIN; 1.
DR PANTHER; PTHR34836:SF1; OS09G0428600 PROTEIN; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037090-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|PIRNR:PIRNR037090};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037090};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037090};
KW Reference proteome {ECO:0000313|Proteomes:UP000230069};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037090}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..839
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013740869"
FT TRANSMEM 581..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 459..795
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DISULFID 745..799
FT /evidence="ECO:0000256|PIRSR:PIRSR037090-50"
SQ SEQUENCE 839 AA; 94075 MW; 90FD49B4C92C4EB3 CRC64;
MKIHDIVHLV LVVFVVLVVC IQLVVAQVTN AIHVGVIMDL ESWTGKVSTS CMSIALDDFY
TIHGDYKTRL VLHTKDSKMD ATGAAFAAME LFKHPGVQVI IGPQKSVQTE FIVDIGEKFQ
IPIITFSATN PSLYSRSQYF IQATPDDHTQ VKAIASVTRA FGWKKVILIH EDTDYGNRLV
PHLINVFQDI NTHILYRSVL PPFPTDDQIV DELHKLMIMH SSVFIVHMSA SFGSQFFLKA
KEVGMMTEGY VWIVTTGLMN VLESLEPTVI DSMQGVVGVT PYIPKSRSLN NFIKRWKRKF
LEDNPDVENV EMISYGLWAY DTVWALARAA ERVGNIKSDF FELGTEGKPP DLLGTRASKT
GPKLLQEILQ TEFEGLSGKF RLVNGHLQPS AFQILNVVGK GGRDIGFWTP THGISKDLNF
QSERKYLATT NRFRGIIWPG ESTIVPKGWV IPVNGKKLRI GVPMPDGFSE LVMVEKDPYT
NVTKVSGYCI DVFDSAIRSL PYNIPYEYVP FQKDGGESYN DIIDQVYLQN YDAVVGDITI
TLNRSLYVDF AFPYTDGGVR MIVPLKEPNT RMFLEPLPKK YWLSSMVVFL FTGFVVWVLE
QVNEFRGTSA NPKVIRIIMS TISLAFRKKL TSFLSKLLVM IWLVILLGWT SGSLVTLKSM
LALQQLEPAT TDFNDLIKHG DFVGYPKGSF VLDLLKRFGF DESKLRTYSS LEECHDLLSK
GSQNGGVAAV FEEIPYAYIF LAKYCSKYTV VGPTHQTDGF GFVFPIGSPL VSDVSKAVLE
VTEGNRLMDQ ERFGPSTTCE EEFTTLTSRY PSFLEISASI LVFSSLFVSS VSHSKAKQS
//
