ID A0A2G5CQ61_AQUCA Unreviewed; 981 AA.
AC A0A2G5CQ61;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Cation chloride cotransporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=AQUCO_04100026v1 {ECO:0000313|EMBL:PIA33320.1};
OS Aquilegia coerulea (Rocky mountain columbine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC Aquilegia.
OX NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA33320.1, ECO:0000313|Proteomes:UP000230069};
RN [1] {ECO:0000313|EMBL:PIA33320.1, ECO:0000313|Proteomes:UP000230069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT "WGS assembly of Aquilegia coerulea Goldsmith.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KZ305058; PIA33320.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5CQ61; -.
DR STRING; 218851.A0A2G5CQ61; -.
DR InParanoid; A0A2G5CQ61; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000230069; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF100; CATION-CHLORIDE COTRANSPORTER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230069};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 133..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 138..608
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 649..770
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 781..980
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 981 AA; 107501 MW; 6B86CDFC835E03E9 CRC64;
MENGEIESQD EELPSRTGRQ YRPVVAHDRA VLEMSSLESA SSSRLPDREM SLKKIKVNAQ
GKMDSNAKED PTQGGPNGPQ RESKLELFGF DSLVNILGLK SMSGEQIPAP TSPRDGEDIS
ITLGHPKPAA VKLGTMMGVF VPCLQNIMGI IYYIRFSWIV GMAGILQSLL LVSFCGLCTF
LTGISLSAIA TNGAMKGGGP YYLIGRALGP EVGVSIGLCF FLGNAVAGSL YVLGAVETFL
NAVPSAGIFQ GSTTSVNTTA GVAEQIQNPS LHDLQVYGIV VTILLVFIVF GGVKMINRVA
PAFLIPVLFS VFCIFIGVFL AKKDDPSPGI TGLSLTTFKD NLGSDYQLTN SAGVPDTNGT
VYWNFNALVG LFFPAVTGIM AGSNRSASLK DTQRSIPVGT LAASLTTTSL YLISVLLFGA
LATREKLLKD RLLTATVAWP LPAIIYVGII LSTLGAALQS LTGAPRLLAA IANDDILPVL
NYFKVADGSE PYIATLFTAF ICIGCVVLGN LDLISPTITM FFLLCYAGVN LSSFLLDLLD
APSWRPRWKF HHWSLSLLGA SLCIVIMFLI SWSFTVVSLA LVSLIYYYVS LKGKAGDWGD
GFKSAYFQLA LRSLRSLGAS QVHPKNWYPI PLIFCRPWGK LPENVPCHPK LADFANCMKK
KGRGMSIFVS ILDGDYHECA EDAKTACRQL STYIDYKRCE GVAEIVVAPN MSVGFRGIVQ
TMGLGNLKPN IVVMRYPEIW RRENLIQIPA VFVGIINDCI VANKAVVIVK GLDEWPNEYQ
RQYGTIDLYW IVRDGGLMLL LSQLLLTKES FESCKIQVFC IAEEDADAEN LKADVKKFLY
DLRMQAEVIV ITMKSWESHV EGNTQQDDSV EAYTAAQQRI AAYLQEMKDK AQREGTPLMA
DGKPVVVNEQ QVEKFLYTCL KLNSTILRYS RMAAVVLVSL PPPPVSHPPY FYMEYMDLLV
ENVPRLLMVR GYRRDVVTLF T
//