ID   A0A2G5CQ61_AQUCA        Unreviewed;       981 AA.
AC   A0A2G5CQ61;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Cation chloride cotransporter {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AQUCO_04100026v1 {ECO:0000313|EMBL:PIA33320.1};
OS   Aquilegia coerulea (Rocky mountain columbine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC   Aquilegia.
OX   NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA33320.1, ECO:0000313|Proteomes:UP000230069};
RN   [1] {ECO:0000313|EMBL:PIA33320.1, ECO:0000313|Proteomes:UP000230069}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA   Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA   Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT   "WGS assembly of Aquilegia coerulea Goldsmith.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KZ305058; PIA33320.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G5CQ61; -.
DR   STRING; 218851.A0A2G5CQ61; -.
DR   InParanoid; A0A2G5CQ61; -.
DR   OrthoDB; 5490251at2759; -.
DR   Proteomes; UP000230069; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF100; CATION-CHLORIDE COTRANSPORTER 1; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230069};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        133..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        166..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        401..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        437..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        492..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        517..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        557..589
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          138..608
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          649..770
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          781..980
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   981 AA;  107501 MW;  6B86CDFC835E03E9 CRC64;
     MENGEIESQD EELPSRTGRQ YRPVVAHDRA VLEMSSLESA SSSRLPDREM SLKKIKVNAQ
     GKMDSNAKED PTQGGPNGPQ RESKLELFGF DSLVNILGLK SMSGEQIPAP TSPRDGEDIS
     ITLGHPKPAA VKLGTMMGVF VPCLQNIMGI IYYIRFSWIV GMAGILQSLL LVSFCGLCTF
     LTGISLSAIA TNGAMKGGGP YYLIGRALGP EVGVSIGLCF FLGNAVAGSL YVLGAVETFL
     NAVPSAGIFQ GSTTSVNTTA GVAEQIQNPS LHDLQVYGIV VTILLVFIVF GGVKMINRVA
     PAFLIPVLFS VFCIFIGVFL AKKDDPSPGI TGLSLTTFKD NLGSDYQLTN SAGVPDTNGT
     VYWNFNALVG LFFPAVTGIM AGSNRSASLK DTQRSIPVGT LAASLTTTSL YLISVLLFGA
     LATREKLLKD RLLTATVAWP LPAIIYVGII LSTLGAALQS LTGAPRLLAA IANDDILPVL
     NYFKVADGSE PYIATLFTAF ICIGCVVLGN LDLISPTITM FFLLCYAGVN LSSFLLDLLD
     APSWRPRWKF HHWSLSLLGA SLCIVIMFLI SWSFTVVSLA LVSLIYYYVS LKGKAGDWGD
     GFKSAYFQLA LRSLRSLGAS QVHPKNWYPI PLIFCRPWGK LPENVPCHPK LADFANCMKK
     KGRGMSIFVS ILDGDYHECA EDAKTACRQL STYIDYKRCE GVAEIVVAPN MSVGFRGIVQ
     TMGLGNLKPN IVVMRYPEIW RRENLIQIPA VFVGIINDCI VANKAVVIVK GLDEWPNEYQ
     RQYGTIDLYW IVRDGGLMLL LSQLLLTKES FESCKIQVFC IAEEDADAEN LKADVKKFLY
     DLRMQAEVIV ITMKSWESHV EGNTQQDDSV EAYTAAQQRI AAYLQEMKDK AQREGTPLMA
     DGKPVVVNEQ QVEKFLYTCL KLNSTILRYS RMAAVVLVSL PPPPVSHPPY FYMEYMDLLV
     ENVPRLLMVR GYRRDVVTLF T
//