ID   A0A2G5D1G0_AQUCA        Unreviewed;       521 AA.
AC   A0A2G5D1G0;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Sulfotransferase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AQUCO_03000148v1 {ECO:0000313|EMBL:PIA37350.1};
OS   Aquilegia coerulea (Rocky mountain columbine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC   Aquilegia.
OX   NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA37350.1, ECO:0000313|Proteomes:UP000230069};
RN   [1] {ECO:0000313|EMBL:PIA37350.1, ECO:0000313|Proteomes:UP000230069}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA   Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA   Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT   "WGS assembly of Aquilegia coerulea Goldsmith.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KZ305047; PIA37350.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G5D1G0; -.
DR   STRING; 218851.A0A2G5D1G0; -.
DR   InParanoid; A0A2G5D1G0; -.
DR   OrthoDB; 1051846at2759; -.
DR   Proteomes; UP000230069; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR010635; Heparan_SO4-6-sulfoTrfase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12812; HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3; 1.
DR   PANTHER; PTHR12812:SF0; HEPARAN-SULFATE 6-O-SULFOTRANSFERASE; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230069};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..521
FT                   /note="Sulfotransferase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013942207"
FT   TRANSMEM        493..512
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          336..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..352
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  60014 MW;  CC4A6C656D6E9408 CRC64;
     MGSARPVALS VLLLLLVFES VNVISNEDEF LKCQRIVRKW SDSSLNEKVK EDKHTLQNLL
     FFLHVPRTGG RTYFHCFLRK LYANNSECPR SYDKLHFDPS KSDCRLLATH DDYSMMSRLP
     KEKTSVVTIL RKPVDRVLST YEFAVEVAAR FLVHPNLTSA TQMTGRVRSK STGVSTLDIW
     PWKYLVPWMR KDLFSRRDNR MHGVLKEFKE SNDPYDVEKI VMPLHEFIND PVAHEIIHNG
     ATFQVAGLTN NSCLPDAHEV RHCVRKYQSL GKYVLEVAKK RLDDMLYVGL TEDHKGSATM
     FANVVGVQIL SQLQELSPTV KKASFNERVL SSSFTESIHD TDHSENSTDE DEVHQFFSTG
     NTKTRNETKT VGQLMESYEV CISSLRKTQA RRRTASLKRV SPANFSKEAR LQIPEMVFQQ
     IISLNNLDVE LYKHAQTIYV QQGKRLVSKK VEVERQKKIS LQRAKHLVSN RVEMERQPNI
     FINSYGPISW NEYSLSIAVL LLLVLIIVIV KVRRRTLKLK I
//