ID A0A2G5EIB2_AQUCA Unreviewed; 3912 AA.
AC A0A2G5EIB2;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PIA55502.1};
GN ORFNames=AQUCO_00700059v1 {ECO:0000313|EMBL:PIA55502.1};
OS Aquilegia coerulea (Rocky mountain columbine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC Aquilegia.
OX NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA55502.1, ECO:0000313|Proteomes:UP000230069};
RN [1] {ECO:0000313|EMBL:PIA55502.1, ECO:0000313|Proteomes:UP000230069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT "WGS assembly of Aquilegia coerulea Goldsmith.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; KZ305024; PIA55501.1; -; Genomic_DNA.
DR EMBL; KZ305024; PIA55502.1; -; Genomic_DNA.
DR STRING; 218851.A0A2G5EIB2; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000230069; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000230069}.
FT DOMAIN 2693..3236
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3541..3864
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3876..3912
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2025..2066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2317..2342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3258..3346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2028..2053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2327..2342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3273..3304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3327..3345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3912 AA; 441108 MW; C69F64B1D856A744 CRC64;
MSPIQNYEQH ARLLLEPNLP IQTRLQMVME VRDSLEIVHT AEYLNFLKCY FRAFSVILTQ
ITTPQLTDNQ EHKLRNIVVE ILNRVPHSEV LRPFVQDLFK LALQVLTSDN EENGLICIRI
IFDLLRNFRP SLEAEVQPFL DFVCKIYQNF RSTVSHFFEE GMGGASTPST LSGPGVSLGG
SISGDDTKPF DGSSPLTGGY IGTGQLNSSS RSFKIVTESP LVVMYLFQLY GRLVQTNIPH
LLPLMVAAIS VPGPEKVAPQ LKNHFIELKG AQVKTVSFLT YLLKSFADYI RPHEESICKS
IVNLLVTCPD SVSIRKELLV ALKHVLGTDF KRGLFPLIDT LLEERVLVGT GRACFETLRP
LAYSLLAEIV HHVRGDLSLS QLSRIIYLFS SNMHDASLSL SIHTTCARLM LNLVEPIFEK
GVDQASMDEA RVLLGRILDA FVGKFSTFKR TIPQLLEEGE EGRERSTLRS KLEIPVQAVL
NLQVPLEHSK EVGDCKHLIK TLVMGMKTII WSITHAHLPR AQVSPSPHGA HPQMQVSPTS
SVPLSQVFKG MKEDEVWKAS GVLKSGVHCL ALFKEKDEER EMLHLFSQIL SIMEPRDLMD
MFSMCLPELF DSMISNSQLL HIFQTLLQLP KVLRPFADVL VNFLASSKLD VLKHPDTPAA
KLVLQLFRYL FGAVAKAPSD CERILQPHVP VIMEVCMKNA TESDRPLGYV QLLRTMFRAL
NGGKFELLLR DLIPSLQPCL NMLLAMVEGP TGEDMRDLVL ELCLTLPARL SSLLPHLPRL
MKPLVMTLKG NDDLVNLGLR TLEFWIDSLN PDFLEPSMAN VMSEVVLALW SHLRPLPYEW
GKKSLQLLGK LGGRNRRFLK EPLALECKEN PEHGLRLVLT FEPSTPFLVP LDRCISLAVA
TVLQTSPGMD AFYRKQALKF LHVCLSSQLN LQGNFTGEGV TPGLLTSLLV SSANPSLRRA
ETSDVKADLG VKTKTQLMAE RSVFKILLMT TIAASAEADL HDPKEEFVVN ICRHFAMIFH
LDTSSASSSF TAAQHGSMLL STSNMSSRSR IAASSNLKEL DPSIFLDALV EVLADENRLH
AKAALDALSV FSETLLFLAH SKHTGILTSR AGPGTPMMVS SPSTNPVCSP PPGVRIPVFE
QLLPRLLHCC YGSNWQMQIG GVMGLGALVG KVTVEILCFF QVRIVRGLVY VLKRLPMHAN
KEQEETSQVL IQVLRVVNNV DEANSEPRRQ SFQSVVEFLA TELFNANASI IVRKNVQSCL
ALLASRTGSE VSELLEPLYQ TLLQPLIMRP LRSKSVDQQV GTVTALNFCL ALRPPLLKLT
QELVTFLQEA LQIAEADEAV WVVKFMNPKV ATSLNKLRTA CIELLCTAMA WADFRTPNHS
ELRAKIISMF FKSLTCRTPD IVAVAKEGLR QVIQQQRMPK DLLQSSLRPI LVNLAHTKSL
SMPLLQGLAR LLELLSNWFN VTLGGKLLEH LKKWLEPEKL AQCQKSWKAG EEPKIAAAII
ELFHLLPQAA GKFLDELVTL TIDLEAALPQ GQYYSEINSP YRLPLTKFLN RYATDAVDYF
LNRLNQPRYF RRFMYIIRSD AGQPLREELA KSPQKILASA FPQFLVKSEE SVASGSVTPP
EACNDDGLVN SLPENLSNQP AGNVAANSDS HFQGLGLISA LVKLMPEWLQ SNRAVFDTLV
FVWKSPARIT RLQNEQELSL VQVKESKWLV KCFLNYLRHD KTEVNVLFDM LSIFLFHSRI
DYTFLKEFYI IEVAEGYPPD MKKMLLLHFL QLFQSKQLGH DHLVVAMQML ILPMLAHAFQ
NGQSWEVVDQ AIVKTIVDKL LDPPEEVTAE YDEPLRIELL QLATLLLKYL QNDLVHHRKE
LIKFGWNHLK REESASKQWA FVNVCHFLEA YQAPEKIILQ VFVALLRTCQ PENKMLVKQA
LDILMPALPR RLPPGDFRMP IWIRYTKKIL VEEGHSIPNL IHIFQLIVRH SDLFYSCRAQ
FVPQMVNSLS RLGLPYNTTA ENRRLAIELA GLVVGWERRR QNEMKAIPDN NIEGSSQTND
VFNPGSTSSD PKRPLDGSIL PDDQSKRVKV EPGLQSLCVM SPGGASSIPN IETPGSSGQP
DEEFKPNAAM EEMIINFLIR VALVIEPKDK EANSMYKQGL ELLSQALEVW PNANVKFNYL
EKLLSSLQPS QSKDPATALA QGLDVMNKVL EKQPHLFIRN NINQISQILE PCFNHKMLDE
GKSLCCLLRM IFIAFPLEAA STPQDVKILY QRVEDLIQKH LAAVTAPQIS LEPNSANVMI
SFALLVIKTL TEVQKNFIDP FILPLARVLQ RLARDMGPPA GSHVRQGQRS DPDSAVSSTR
SVADIGSVTS NLKSVLELIS ERVMLVPECK RSISQILNTL LSDKGIDASV LLCILDVLKG
WIENDFNKQV TTNVPSSVLT PKEIVSYLQK LSQVDKQNFS PSSLEEWERK YLQLLYGICA
DSNKYPLSMR QEVFQKVERQ FMLGLRAKDP QIRQQFFSLY HDSLGKTLFT RLQYIIQIQD
WQLLSDVFWL KQGLDLLLAI LVENEPIALA PNSARVPPLV TAASLSDRSV TSQQSTDAPM
DSEGGQLTFS GLVYKHAQFL NEMSILQVSD LIIPLRELAH IDANVAYHMW VLVFPIVWVT
LQKEEQVALA KPMIALLSKD YHKKQQASRP NVVQALLEGL HLSHPQPRMP SELIKYIGKT
FNAWHISLAL LESHVMLFMN DTKCSESLAE LYRLLNEDDM RCGLWKKRSI TAETRAGLSL
VQHGYWQSAQ SLFYQAMIKA TQGTYNNTVP KAEMCLWEEQ WLYCASQLSQ WDVLADFGKS
VENYEILLDS LWKVPDWAYM KDNVIPKAQV EETPKLRIIQ AFFSLHDRST NGVGDANSIV
EKGLDLSLEQ WWQLPEMSVQ SRMPLLQQFQ QLVEVQESAK IILDIANGNK QLSGSSVGGV
HGGYMELKDI LETWRLRTPN EWDNLSVWYD LLQWRNEMYN AVIDAFKDFG STNPQLHHLG
YRDKAWNVNK LAHIARKQGI YDVCVTVLEK MYGHSTMEVQ EAFIKIREQA KAYLEMRGEL
TSGLNLINST NLEYFPVKHK AEIFRLKGDF LLKLGDCENA NLAYSNAISL FKHLPKGWIS
WGNYCDMIYK ETQEEFWLEY AVSCFLQGIK FGVSNSRSHL ARVLYLLSFD TANEPVGRAF
DKYLEQIPHW VWLSWVPQLL LSLQRTEAPH CKLVLAKIAT VYPQALYYWL RTYLLERRDV
ANKSELGRNL AMAQQRMQQN VSGAGAGSLG LGDNSARGQN HVGGTSNSDN QVQQGSQSGS
AGGPHDGGNS HGQELERAPA VEGSMHDQPL QQGSSTMNEG GQSTLRRSGA VELVASAATA
FDAAKDIMET LRSKHANLAS ELEILLTEIG SRFVTLPEER LLAVVNALLH RCYKYPTATT
AEVPQSLKKE LSGVCRACFS ADAVNKHVDF VREYKQDFER DLDPESASTF PCTLSELTER
LKHWKNVLQS NVEDRFPAVL KLEEESRVLR DFHVVDVEVP GQYFTDQEVA PDHTVKLDRV
GADIPIVRRH GSSFRRLTLI GSDGSQRHFI VQTSLTPNAR SDERILQLFR VMNRMFDKHK
ESRRRHLSVH TPIIIPVWSQ VRMVEDDLMY STFLEVYEVN CARNNREADL PITHFKEQLN
QAISGQISPE AVLDLRLQAY NDITKTLVND NVFSQYMYKT LPSGNHLWAF KKQFAIQLAL
SSFMSFMLQI GGRSPNKILF AKNTGKIFQT DFHPAYDANG MIEFSEPVPF RLTRNMQAFF
SHFGVEGLIV SAMCAAAQAV VSPKQNQHLW HQLAMFFRDE LLSWSWRRPL VMPSAPINGG
GGMNAMEFKH KVTNNVEHVI ERIKGIAPQY AEEEENTMDP PHSVQRGVTE LVEAALTPRN
LCMMDPTWHP WF
//
