ID   A0A2G5EPL0_AQUCA        Unreviewed;       662 AA.
AC   A0A2G5EPL0;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=CYTH domain-containing protein {ECO:0000259|PROSITE:PS51707};
GN   ORFNames=AQUCO_00600329v1 {ECO:0000313|EMBL:PIA57537.1};
OS   Aquilegia coerulea (Rocky mountain columbine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC   Aquilegia.
OX   NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA57537.1, ECO:0000313|Proteomes:UP000230069};
RN   [1] {ECO:0000313|EMBL:PIA57537.1, ECO:0000313|Proteomes:UP000230069}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA   Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA   Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT   "WGS assembly of Aquilegia coerulea Goldsmith.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KZ305023; PIA57537.1; -; Genomic_DNA.
DR   EMBL; KZ305023; PIA57538.1; -; Genomic_DNA.
DR   STRING; 218851.A0A2G5EPL0; -.
DR   OrthoDB; 180154at2759; -.
DR   Proteomes; UP000230069; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR   GO; GO:0016462; F:pyrophosphatase activity; IEA:UniProt.
DR   CDD; cd02028; UMPK_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR033469; CYTH-like_dom_sf.
DR   InterPro; IPR023577; CYTH_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006083; PRK/URK.
DR   PANTHER; PTHR10285; URIDINE KINASE; 1.
DR   PANTHER; PTHR10285:SF122; URIDINE-CYTIDINE KINASE C; 1.
DR   Pfam; PF01928; CYTH; 1.
DR   Pfam; PF00485; PRK; 1.
DR   PRINTS; PR00988; URIDINKINASE.
DR   SUPFAM; SSF55154; CYTH-like phosphatases; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51707; CYTH; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230069};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        637..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          248..410
FT                   /note="CYTH"
FT                   /evidence="ECO:0000259|PROSITE:PS51707"
FT   COILED          504..531
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   662 AA;  74173 MW;  66C4668D8829B9FA CRC64;
     MAKDASGPDS PHRKHGLLRD QVQLVKKRDS DRYEIVPIQD LLSFEKGFFI VIRACQLLAQ
     KNEGIILVGV AGPSGAGKTV FTEKVLNFMP SIAVISMDNY NDASRIIDGN FDDPRLTDYD
     TLLENIHGLK EGKPVQVPVY DFKSSSRTGY RTIEVPSSRI VIIEGIYALS EKLRPLLDLR
     VSVTGGVHFD LVKRVLRDIQ RAGQEPEEII HQISETVYPM YKAFIEPDLQ TAHIKIRNKF
     NPFAGFQNPT YILKSTRTVT VDQIKAVISG ECKDHMEEIY DIFLLPPGED PEACQSYLRM
     RNRDGKYNLM FEEWVTDSPF MISPRITFEV SVRLLGGLMA LGYTIATILK RSSHVFFNDR
     VCVKIDWLEQ LNRQYVQVQG RDRLYVKFIA EELGLEGSYV PRTYIQQIQL EKLVNEVMAL
     PDDLKTKLSI DEDLVSSSPK EALSRASADR IAMRNKHSKS GMSQSYSTHG DKNPFKLTRL
     SVNNQKFDGG NLESPAAVTN QGVINQLLEQ ISTLNERIDE FTSRIEELNS KFKTRNVSGS
     QQNLSLQAEP CNGSGQTSFF VSGLGNGSLT GSLLPNSSSS SQLAREAPLM EEVAVIARGQ
     RQLMHQLDNL SNFVHENIEQ SRHGRTEGSR LTNFEHIGIP VLLSLAIGGV GILLFKGLSS
     QN
//