ID A0A2G5EPW3_AQUCA Unreviewed; 711 AA.
AC A0A2G5EPW3;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AQUCO_00600468v1 {ECO:0000313|EMBL:PIA57760.1};
OS Aquilegia coerulea (Rocky mountain columbine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC Aquilegia.
OX NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA57760.1, ECO:0000313|Proteomes:UP000230069};
RN [1] {ECO:0000313|EMBL:PIA57760.1, ECO:0000313|Proteomes:UP000230069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT "WGS assembly of Aquilegia coerulea Goldsmith.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KZ305023; PIA57760.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5EPW3; -.
DR InParanoid; A0A2G5EPW3; -.
DR OrthoDB; 1753647at2759; -.
DR Proteomes; UP000230069; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF109; CSC1-LIKE PROTEIN HYP1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230069};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..167
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 188..345
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 358..622
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT COILED 275..302
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 711 AA; 80355 MW; 9EC86CF7B919CDFE CRC64;
MILSALLTSV GINLLLCILF FTLYSILRKQ PSNIDVYAPR LVAEGKAHSS AFSLERLLPS
PGWVRRAWQL SEDELLSAAG LDGVVFMRIF TFSLKIFSFM GLVGILILLP INYVGKQLNA
FDISDLPNKS LDAFSISNLE DGSKRLWVHF VALYLATGVV CYFLYHEYRY ISLKRLDLFY
SSKPQPHQFT ILVRSIPKSS EGTSSDSVES FFAEYYPSIY LSHTMVCRTS KLQGLITDAK
KLYKKLTDLK SDAHAQHKSR RSGFLGLWGQ KVTLVDHYGK KLEDLEENVR MEQSDVSLAR
EELPEAFVSF KTRYGASTAL HIKQSDNPAE WVTEIAPEPS DVYWPFFYAT FLPRWISKLI
VIVATIILTL LFLIPVAFVQ GLANASQLVK WLPFLKGILT IAFVSQVITG YLPSLILQWF
LSIVPPIMKI FSSMQGYISN SEIEKSACTK VLWFTIWNVF FANVLTGSAF STFQFFLDFK
DIPQTLAIAV PGQASFYISY VVTSGWTSVS SELFRMSPLF WSTITSCARG SDNEVDVSSV
PYTSVIPRIL LFVLLGITYF FLAPLILPFV LAYFCLGYVV YRNQLINVYA PKYDTAGKFW
PIVHNSTIFS LVLVQALAVG LFGLKQLPLA STLTFPLIVL TLLFNEYCRK RFLPIFQTYS
AESLIKKDRK DSSDPAMTDF LDKLVTAYRD PALMPIHYSQ NANDHNTPLL T
//
