ID A0A2G5EWQ2_AQUCA Unreviewed; 887 AA.
AC A0A2G5EWQ2;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AQUCO_00400805v1 {ECO:0000313|EMBL:PIA60160.1};
OS Aquilegia coerulea (Rocky mountain columbine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC Aquilegia.
OX NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA60160.1, ECO:0000313|Proteomes:UP000230069};
RN [1] {ECO:0000313|EMBL:PIA60160.1, ECO:0000313|Proteomes:UP000230069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT "WGS assembly of Aquilegia coerulea Goldsmith.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KZ305021; PIA60160.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5EWQ2; -.
DR STRING; 218851.A0A2G5EWQ2; -.
DR InParanoid; A0A2G5EWQ2; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000230069; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00821; PH; 1.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR025757; MIP1_Leuzipper.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46265; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR PANTHER; PTHR46265:SF2; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR Pfam; PF14389; Lzipper-MIP1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000230069}.
FT DOMAIN 20..127
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 173..373
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 384..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 622..656
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 416..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 98208 MW; DF0126A7A6FBE1CF CRC64;
MSGSFGPLEG PRNGVSGSNT VYKSGPLLIS SKGIGWKSWK KRWFILTRTS LVFFKNDPSE
LPQRGGEVNL TLGGIDLNNS GSVVVREDKK LLTVLFPDGR DGRGFTLKAE SSEDLYEWKT
ALEHALAQAP SAALVMGHGI FRNDASDTVE GSFQQWRDKH PVKSLVVGRP ILLALEDIDG
SPSFLEKALC FLEKFGTKVE GILRQSADVE EVDRRVQEYE QGKSEFESDE DAHVVGDCVK
HVLRELPSSP VPASCCTALL EAYRVEGKAD RVVALRSAIY DTFPEPNRRL LQRVLKMMHK
ISAHSADNRM TPSAVAACMA PLLLRPLLAG ECELEDDFDM NGDDSAQLLA AANAANNAQA
IVTTLLEEYD NVFPGVNLHG CSLSVDPQME NSESEDSTDD GNSNTKDISY HDAANEVNPE
FEDDSERVLS GKLSETSGYS GSDLYDNKVC VDDLDVESPE RKHSSPRKLL SEKSVRDTNG
IFKTHNTLKN ESEVSIKVMD SPSALVANGS HRSTGDRLTS VDTRIPSHAP SPELCLEKST
VKPNGSKNNV KRSNFWGRSN TRRNTSVDSV DLSGDEETFQ SGFSYKLMQS RLFRLAIQRL
EIAKNDLLNR IAKEAKGNAI LQASLERRKQ ALHERRLALE QDVSRLQEQL QAERDLRAAL
EVGLSMSSGQ FSDSRGMDSK TRAELEEIAL AEADVAKLKQ KVTELHHQLN QQRQQHYGSL
SDASNRHQHA QNLHSQLKFM QQDFDMNLAF CNHERKQRTE ESSLGADWKS LKAQLLSAAS
NSKQHSRKQL ANLTSPSDSR STEASTSFSA DNFSAIDSAT MPTTSREMEG LGNQRQTAPS
SSTLVELTTR LDFFKERRSQ LMEQLHNLDL ASSPQGMVHS PPSPSWR
//
