ID   A0A2G5F1M0_AQUCA        Unreviewed;       812 AA.
AC   A0A2G5F1M0;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Cation/H+ exchanger domain-containing protein {ECO:0000259|Pfam:PF00999};
DE   Flags: Fragment;
GN   ORFNames=AQUCO_00200124v1 {ECO:0000313|EMBL:PIA61913.1};
OS   Aquilegia coerulea (Rocky mountain columbine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Thalictroideae;
OC   Aquilegia.
OX   NCBI_TaxID=218851 {ECO:0000313|EMBL:PIA61913.1, ECO:0000313|Proteomes:UP000230069};
RN   [1] {ECO:0000313|EMBL:PIA61913.1, ECO:0000313|Proteomes:UP000230069}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Goldsmith {ECO:0000313|Proteomes:UP000230069};
RA   Hodges S., Kramer E., Nordborg M., Tomkins J., Borevitz J., Derieg N.,
RA   Yan J., Mihaltcheva S., Hayes R.D., Rokhsar D.;
RT   "WGS assembly of Aquilegia coerulea Goldsmith.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC       {ECO:0000256|ARBA:ARBA00038341}.
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DR   EMBL; KZ305019; PIA61913.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G5F1M0; -.
DR   InParanoid; A0A2G5F1M0; -.
DR   OrthoDB; 605010at2759; -.
DR   Proteomes; UP000230069; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR   PANTHER; PTHR32468:SF35; CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230069};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        37..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        137..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        235..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        275..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        323..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        352..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          50..433
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   NON_TER         812
FT                   /evidence="ECO:0000313|EMBL:PIA61913.1"
SQ   SEQUENCE   812 AA;  89343 MW;  44CFE0EA0912876E CRC64;
     MSINRTYSIL NSSYVCQYPG ENIPVNSKGV FLRDDPLFYA VPLLMLQLSI ITLTSYAANY
     CLKPLGQSSI VAQMLAGIIL GPSLLGRSKA FSNTVFPIGS NTALETIATF GAMFFLFQNG
     LKTDPGMIRI NGQKSIIIGV LAFGTPLVLS VLLAFILTHF IDMDKSLADS LHLIAGSQAL
     TGFIVIACHL TELKIVNTDL GRLAVSAAIV GDLLGISTTA LYFASQQSKA DPLDAILGIV
     STLLLVAFIV YGIRPLTLHM IKGTPGGETV KEVHVFALFL AILIVGFISE TIGQHFVLGP
     LILGLALPDG PPLGSELVRK LDSLVSFLLF PTYLAVSGLK TNVDSLSLKS SLLVMLIVVF
     AGFVKVVATM LPCLYLNMAW RDAFVLGLTM NTKGIVELLL YNIWKDAQIL EDQEFALTVL
     SVLLLTAVIS PLTRALYDPS KRFISSKKNN IQHAKRNAEL RILVCIHKQE NVPSIINILE
     ISHPTTEAPI CVIILQFVEL MGRCTPILVA HKPDHNFMCG NVRTQNIVNA FTQFEMQSQG
     ITSMHPFTAI AHFATMHDDI CNLAIDKKVN FVITPFHKEW DIDGRVGMEN RSIRTMNRNI
     LEKLPCSVGI FIDRNVQSGS LSVLTSRAFY CVGVIFMGGA DDGEALAYGA RMAEHPQVNL
     TIIRFLVFGC DNARDRKFDN DVIDEFKFNT AYNKRIEYRD EVVRDGEGFS LALKELGKGY
     DLVLVGRHQK TETPLLSGLT DWNECPELGI VGDMLASTDF KGMCSVLNFD GEISLIRFYS
     KLIHQDPPSQ LENSSLLLNR ETFDCMNPNL LE
//