ID A0A2G5IJ61_9ACTN Unreviewed; 389 AA.
AC A0A2G5IJ61;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=B1C81_32605 {ECO:0000313|EMBL:PIB04524.1};
OS Streptomyces sp. HG99.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1958787 {ECO:0000313|EMBL:PIB04524.1, ECO:0000313|Proteomes:UP000231274};
RN [1] {ECO:0000313|EMBL:PIB04524.1, ECO:0000313|Proteomes:UP000231274}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HG99 {ECO:0000313|EMBL:PIB04524.1,
RC ECO:0000313|Proteomes:UP000231274};
RA Li Y.;
RT "Diversity and bioprospecting of biosynthetic gene clusters of culturable
RT actinobacteria from Tibetan Plateau, China.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIB04524.1}.
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DR EMBL; MVDM01000032; PIB04524.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5IJ61; -.
DR Proteomes; UP000231274; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.60.260.20; Urease metallochaperone UreE, N-terminal domain; 1.
DR InterPro; IPR002939; DnaJ_C.
DR InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF32; SERINE_THREONINE-PROTEIN KINASE PKAB; 1.
DR Pfam; PF01556; DnaJ_C; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49493; HSP40/DnaJ peptide-binding domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:PIB04524.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000231274};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:PIB04524.1};
KW Transferase {ECO:0000313|EMBL:PIB04524.1}.
FT DOMAIN 6..274
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 35
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 389 AA; 41790 MW; E392192ED1020B54 CRC64;
MLDGRYRLIE PVGAGGFGQV WRAHDPRVDR LVAVKVLTSD GSTDHDRQVA RFAREAAVAG
GLSHPHIVTV HDFGSAVRHG RPYAYLVMQL LPGKSLSAVL EAGQLPLPTA LYAASCVADA
LDAAHEAGLT HRDIKPSNIM VRDDGEATVV DFGITKGSND ARHDITTTGV LIGTPAYMAP
EALSGSFDHR SDLYSLGCVL FEAVTGRRPF TGTSWQLINQ HLKEPPALLR TLRPDAPVEL
ERLVSRLLAK NPAQRPDSAD EVYDLLEEIN DSYFGDTRPI SAPPSSRGAD ITSEVHLHPD
EATAGAVIPL RLTARETCLA CAPRGDETRV LACTACKGEG RIVRDQRTLK VRIPAGVKDG
QKVRLRELGA PGQHGGAPGD LYVTVHVTS
//
