ID A0A2G5KJ16_9FLAO Unreviewed; 2125 AA.
AC A0A2G5KJ16;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Alpha-2-macroglobulin {ECO:0000313|EMBL:PIB29102.1};
GN ORFNames=BFP77_07830 {ECO:0000313|EMBL:PIB29102.1};
OS Maribacter sp. 4U21.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Maribacter.
OX NCBI_TaxID=1889779 {ECO:0000313|EMBL:PIB29102.1, ECO:0000313|Proteomes:UP000243243};
RN [1] {ECO:0000313|EMBL:PIB29102.1, ECO:0000313|Proteomes:UP000243243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4U21 {ECO:0000313|EMBL:PIB29102.1,
RC ECO:0000313|Proteomes:UP000243243};
RA Wong S.-K., Hamasaki K., Yoshizawa S.;
RT "Draft genome of Maribacter sp. strain 4U21.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIB29102.1}.
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DR EMBL; MDGN01000034; PIB29102.1; -; Genomic_DNA.
DR Proteomes; UP000243243; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF13715; CarbopepD_reg_2; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000243243};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2125
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013646857"
FT DOMAIN 975..1115
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1358..1448
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 2125 AA; 242452 MW; C9BF7BB0726580DD CRC64;
MKTLIATLSV ILFSQVLPAQ EPNLSYEQLW AKVHKLEREV LTKSALEIVE TINAKAKKEE
QHSQVIKSLL FKAKYGLILE EDAKLKTITN LKVEISKANF PVKNVLESYL ANLYWQYYQQ
NRYQFYNRTA TDTKIDSVDF RTWDLTTLFN EISFRFEQSL ANPKKLQKET LKDFKEILYE
QEGSKTFRPS LFNVLAHTAL DFYKTNENSI TRPADKFEIS DPELLCEAYG FTQLNIPMDD
KTSLQQRALG IYQQLLTFHF PNPRLDALVT VDIERLRFIH TNAVFEDKDQ VYLSVLQQSA
ERLVQHEVSA LYNHEIAQLL QHQGNTYNAT NEATQWKLKE AIAIYDATIA QFPDSRGGQK
CAALKSRILA SELQLTSEKQ LAVSKPSRLL VNYKNHKSLN LKAYAISQIQ RKKLEELYPI
KKQLAYIQDL KTRASWTVQL KDEGDYQRHS IEIPLPALEA GQYVIVATGA DTNEKSNTEK
SFAFSTLQVT DLAFTETKMP NQHIFQVVDR NTGKPKAGAE ITLYYRKNYR GSILRKSLVT
DKNGFSAMDL NRSSISIETT KIEHGKETAF FEGTYINQKR RDTKKPQITY KAFVFKDRSI
YRPGQALYFK GILIENDDTV SQVASEETVT VGLYDVNGQK VSEMDLQTND FGSFTGEFIL
PNTGLTGMFY LEVYGVSGLV DQDFYFFVEE YKRPKFETSF KPVTETYRVN DSITVKGTAN
AFAGSTISGA KVSYRVQRNV NYPQWYYWSR PYNYGEPQEI GLGETTTDSN GSYEITFKAL
PDLSADKANL PTFSYYVTAD VTDINGETRS TATTVQVGYH AMTASIMVDE PLNTTAKNQK
INISTQNLNG QNVFAKGVLK MYKLKAPEYV LRDRPWPAPD YNYWGKKDFK TLYPHDSYSN
EHDPKTWEKG KLVLETDFDT EKSTHITLKN LKKWNSGLYI IELETKDIFG QKVTAKTKTS
VHNGKEKIRA DNQLFHVKTD KPFYTVRDMA EITFYSNAKD SYVTVLVEKD KKLIRKEILR
FEQGCETITV PVTAKDLGGF TVKYHFTVFN SFRAGSAPIS VPYPNTDLEI ETLNFRDKLQ
PGTDETWSFK IKGPEGEKVT AELLTSMYDA SLDQFRGHSW NFNPIARPYY YSDSYTNASQ
SFGTKSFRKY DANFLIDAVP ALSFDSFEWF GLDFRNPRYA QRNYLKRRQA SLRNASYVDA
TIKKGYISGT VYDQDGQPLP GVNVVISGTT EGTQTDFDGN FSIKAAVGQE LILTFIGQVT
LRQKVSTDNF YAFYMQEDSA ALEEVVVMGY GTQKRKSVTG AVAIEMAEDN MEMKAADALQ
GRAAGLSISA APLPEETSET QKPVDFTDIK IRKNLQETAF FFPQLRTDKD GTVSFSFTTP
EALTRWNVQL LGYTKDLKTA SIRLSAVTQK ELMVLPNPPR FLREGDEITI SSKISNLSNK
YLSGSGQLEL TDVITGKSID SLLKNNLKTQ DFQVDAKGNT QLSWTISIPK GLQGVQYKIV
AKAGDFSDGE QNILPVLTNR MLVTETLPMW VRSNQTKTFT LGKLKDNTST TLSNHKLTLE
MTSNPAWYAV QALPYLMEYP YECNEQTFSR YYANTLATHI ANSNPRIEEV FQQWANTDAL
LSNLEKNQEL KSLLIQETPW LRDAQSESQQ KKRIGLLLNL NKMKSEQEIA LRKLENNQMY
SGAWPWFNGG RENRYITQHI ITGLGHLRHL SVAADDKELR MIKKAVRYLD NAFVEEYRQM
KKYATDLSKD HLSNTQIQYL YMRSFFEDIK TSKQVDEIST YYLGQSRKYW TKRNLYTKGM
LALVMQRNGD EKTATKILRS LKENSIVSDE LGMYWKENTS SWYWYQAPIE TQALLIEAFS
EIDGDLTTID NLKIWLLKNK QTNQWKTTKA TTEAVYALLL KGSDWLSVTE AVSVLVGGEK
LAPSKLENVK IEAGTGYYKT SWAGSEVESK MAEVQIAKKG EGIAWGALYW QYFEDLDKIT
SAETPLQLKK KLFLKKNTGT GETISEITKS TELKVGDLVR VRIELKSDRN MEFLHMKDMR
AAGFEPINVL SQYKWQDGLG YYESTKDAST NFFFDYLPKG VYVFEYDVRV NNSGDFSNGI
TSIQSMYAPE FSSHSEGVRV KVTNE
//