ID A0A2G5KZ77_9BACT Unreviewed; 620 AA.
AC A0A2G5KZ77;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=BFP72_04210 {ECO:0000313|EMBL:PIB34669.1};
OS Reichenbachiella sp. 5M10.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Reichenbachiellaceae;
OC Reichenbachiella.
OX NCBI_TaxID=1889772 {ECO:0000313|EMBL:PIB34669.1, ECO:0000313|Proteomes:UP000229466};
RN [1] {ECO:0000313|EMBL:PIB34669.1, ECO:0000313|Proteomes:UP000229466}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5M10 {ECO:0000313|EMBL:PIB34669.1,
RC ECO:0000313|Proteomes:UP000229466};
RA Wong S.-K., Hamasaki K., Yoshizawa S.;
RT "Draft genome of Reichenbachiella sp. strain 5M10.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIB34669.1}.
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DR EMBL; MDGR01000007; PIB34669.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5KZ77; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000229466; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000229466}.
FT DOMAIN 209..327
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 436..577
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 352..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 70085 MW; A4B2E18D0EA4B48E CRC64;
MPDIIHLLPD AIANQIAAGE VVQRPASVVK ELLENSIDAG STKIHLIVND AGKNLIQVVD
NGKGMSETDA RMSFERHATS KIQKSEDLFK IQTMGFRGEA LASIAAVARV ELKTKTEYNE
LGTSIVIEAS EVKSQSPESA NQGTSLSVKN LFYNVPARRN FLKSNPVEMR HIMDEFHRVA
LSNPHVNFIL TQNEKEIYNS PSGKLSQRIV QLFGKNYQSQ LIACQEETEW LKVSGYIGKP
EHSKKTRGEQ FFFVNNRFIK SSYLNHAVQG AFEGLIKDDQ HPFYTLFIEM DPARIDINVH
PTKTEIKFDD ERSVYGIIKS AVKQALGTHN VTPSLDFDMD VNFTNFAAHS TKFESQQSST
KDRGYGNFKS IDQKQGKSTR WERLYESAIH ESSLSPAEIR QEEMAGFDQI QPEEKQEKTQ
LEISSQMSTD NYSSEPILMH EKYIMKQVKS GIMILDAVLA HERILFEKYI STLNEHTGMS
QKCLFPVHIE LGPADFSLVM DLQAEITALG FEFEVFGDHS IAINGVPADV QNINEKELFE
GLIEQFKFNK SELSINTREN IARSIAKRSS NRTKISKQTL ELKSLIDRLF ACDQPNYAPN
GTPTFVILGL DKIVEFFKYQ
//
