ID A0A2G5P7J6_9MYCO Unreviewed; 392 AA.
AC A0A2G5P7J6;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Type III polyketide synthase {ECO:0000313|EMBL:PIB73993.1};
GN ORFNames=CQY22_014600 {ECO:0000313|EMBL:PIB73993.1};
OS Mycolicibacterium brumae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=85968 {ECO:0000313|EMBL:PIB73993.1, ECO:0000313|Proteomes:UP000230551};
RN [1] {ECO:0000313|EMBL:PIB73993.1, ECO:0000313|Proteomes:UP000230551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP1034565 {ECO:0000313|EMBL:PIB73993.1,
RC ECO:0000313|Proteomes:UP000230551};
RX PubMed=29030295; DOI=10.1016/j.meegid.2017.10.013;
RA Tortoli E., Fedrizzi T., Meehan C.J., Trovato A., Grottola A.,
RA Giacobazzi E., Serpini G.F., Tagliazucchi S., Fabio A., Bettua C.,
RA Bertorelli R., Frascaro F., De Sanctis V., Pecorari M., Jousson O.,
RA Segata N., Cirillo D.M.;
RT "The new phylogeny of the genus Mycobacterium: The old and the news.";
RL Infect. Genet. Evol. 56:19-25(2017).
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIB73993.1}.
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DR EMBL; PDCN02000021; PIB73993.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5P7J6; -.
DR STRING; 85968.GCA_900073015_03685; -.
DR OrthoDB; 9786288at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000230551; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000230551}.
FT DOMAIN 34..236
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 252..388
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 174
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 392 AA; 41675 MW; 3B3FD71825B4709F CRC64;
MSIDFERSRE IAIPGYVERS RTVLPLPAPP TSVAVIESLA TGAPPTTVPQ RALAEQVCGL
YEDPVQRERI GRIFAKTGII TRQLAVDPLA DGAAEFRRRR GTVRERMELF REHGVPLAVD
VAGRALAGLD PADIGLVVFA TSTGLIAPGI DIEVVRRLGL PITTARVVIN FMGCAAAMNA
IRTASDFARA NPARKALVIC MELSSVNAVF SDDVNDIVIS SLFGDGCGAV VVGAKPAGHQ
LRRGQLVIRD SFSQLLDDSA DGIVLGVNDN GITCELAEEL PNYIYAGVKP AIDAALDRNG
LRRKDIDMWA IHPGGPKVIG ESLHSLQLAP AVAEASWAVL AEYGNMLSVA LLFVLQRLLA
DDTAGAPIET GVAFSFAPGV VLEGLIFDVV RR
//
