ID A0A2G5PDU9_9MYCO Unreviewed; 972 AA.
AC A0A2G5PDU9;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=MMPL family transporter {ECO:0000313|EMBL:PIB76511.1};
GN ORFNames=CQY22_005155 {ECO:0000313|EMBL:PIB76511.1};
OS Mycolicibacterium brumae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=85968 {ECO:0000313|EMBL:PIB76511.1, ECO:0000313|Proteomes:UP000230551};
RN [1] {ECO:0000313|EMBL:PIB76511.1, ECO:0000313|Proteomes:UP000230551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP1034565 {ECO:0000313|EMBL:PIB76511.1,
RC ECO:0000313|Proteomes:UP000230551};
RX PubMed=29030295; DOI=10.1016/j.meegid.2017.10.013;
RA Tortoli E., Fedrizzi T., Meehan C.J., Trovato A., Grottola A.,
RA Giacobazzi E., Serpini G.F., Tagliazucchi S., Fabio A., Bettua C.,
RA Bertorelli R., Frascaro F., De Sanctis V., Pecorari M., Jousson O.,
RA Segata N., Cirillo D.M.;
RT "The new phylogeny of the genus Mycobacterium: The old and the news.";
RL Infect. Genet. Evol. 56:19-25(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIB76511.1}.
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DR EMBL; PDCN02000004; PIB76511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5PDU9; -.
DR STRING; 85968.GCA_900073015_03567; -.
DR OrthoDB; 4656631at2; -.
DR Proteomes; UP000230551; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230551};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..942
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..397
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 619..953
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 951..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 106530 MW; 1CF2EB51B14A2AE3 CRC64;
MTAPAPETQK PGEEPFGHVK RDGLARLIRA LAVPIVIAWV LLVVVLNTVV PQLEKVGAMR
SVSMSPNDAP SVIAMMRVGE TFQEFKSNSS VMIVLESEGE QLGQEAHDFY DEIIRRLEAD
DVHVEHVQDF WGDPLTAAGS QSPDGHAAYV QIYTAGNQGE ALANESVEAV QKIVADVQAE
RAPPGVTAYV TGPAALSADQ TIAGDRSMRS IELVTFAIII TMLFLVYRSF VTVALALLMV
VFSLAAARGA VAFLGYHDIM GLSTFATSLL VTLAIAASTD YAIFLIGRYQ EARSRGMDRE
TAYYDMFHGT GHVIMGSGLT IAGATACLHF TRMPYFQSLG FPLAVGMTIV VVCALTLGSA
IISIATRFGK ILEPKRAVRT RGWRKVGAAV VRWPGPILIA TIALSLVGLL ALPGYRTNYN
DRHYLPDDLP ANAGYAAADR HFSQARMNPE LLMIETDHDL RNSADFLVID KVAKQIFRVP
GVGRVQAITR PQGTPIEHTS IPFQISMNGV TQQMNEKYQQ DMMANMLKQA EDMQVTIDNM
TKMSSITEQM AETTHSMVTK MKNMVLDVAE MRDHISDFDD LMRPIRNYLY WEPHCFNIPV
CWAMRSIFDT LDGIDVMTDD IQQIVPDMER LDTLMPQMVA LMPSMIDTMK RMKNYMLTMY
QTQKGMQDQI SSMQENSTAM GKAFDDAKND DSFYLPPEVF DNPDFKRGIK MFLSPDGHAV
RFIISHDGDP MTPEGIEKIA SIKQAAREAV KGTPLEGSKI YLGGTAATFK DMQDGANFDL
IIAGIAALAL IFLIMLIITR AIVAAAVIVG TVVFSLGASF GLSVLIWQHI IGLELHWMVL
AMAVIILLAV GADYNLLLVA RFKEEIHAGL NTGIIRAMGG TGSVVTAAGL VFAFTMMGMV
VSELAIIGQV GSTIGLGLLF DTLVIRSFMT PAIAALLGKW FWWPQRVRQR PLPSPWPKPP
ARDDETTPVP TA
//
