ID A0A2G5SB11_9PELO Unreviewed; 627 AA.
AC A0A2G5SB11;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=B9Z55_028648 {ECO:0000313|EMBL:PIC12093.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC12093.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC12093.1}.
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DR EMBL; PDUG01000028; PIC12093.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5SB11; -.
DR Proteomes; UP000230233; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13388; PH1_FGD1-4_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF241; PROTEIN CBG10230; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000230233}.
FT DOMAIN 296..479
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 508..609
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 255..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 72312 MW; 301640D02F0A2F45 CRC64;
MSSSVQLPTQ MPSGFQMNFD DVRRHLMAPK VDYEGGTLKK MEEVEEIDQS DGCTIRIFTY
FILLPNNEEL IKTVRQKVKV ECKKTQRSVR MVGSEAKEVT ENCQQLSGDI KGMRPVEYSD
DSRQTCLVQH NVQLDLSDEQ DQRIDRCLKQ VPVTIINMLS KQKEMFVQEY PEFVEKMRSE
SSQIPSTTTE VITNEDRSTM TRVRSSKSYS SHFSRQESYV NGVKKMSKSR FRAFVVYQGP
EGGFQVKLLD SDELSEDELE EDDTKSQSRF SEIDDADSEI TPGPSTSSNL EKRYQNAWYA
AQELVDSEQR YVEKLKLLGD TFRNRLIKEK VLTDDKITQL LANVSSLYEL HHTHFLPQLM
ISIRDWHTTK RIADVVKKQA PFFKMYSAYT NNFDRACKLF EELKKKKKFA DLVKDIEKQP
ECDGLPLVCH LICPVQRLTR YQLLLQEYKK HLQPSDGDFK DTVDALDLVL AAAAHSNEMM
KKVHRFEKVI EVQEQLGNSI FLVSPERELL KSGPIQQISP TTEKTEEQFL FLFNDLVILA
GELSKSKYKL RAVFSASHLQ VCEGDNLERD HSFYLRGSNR TGSEQCVELF TPTQKEKNEW
VDLIFSIIDE ARVNSSMLTT SSVSFCI
//
