ID A0A2G5SJM3_9PELO Unreviewed; 2274 AA.
AC A0A2G5SJM3;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN Name=Cnig_chr_X.g22183 {ECO:0000313|EMBL:PIC15066.1};
GN ORFNames=B9Z55_022183 {ECO:0000313|EMBL:PIC15066.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC15066.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMC family. {ECO:0000256|ARBA:ARBA00006510}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC15066.1}.
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DR EMBL; PDUG01000006; PIC15066.1; -; Genomic_DNA.
DR STRING; 1611254.A0A2G5SJM3; -.
DR Proteomes; UP000230233; Chromosome x.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR CDD; cd09275; RNase_HI_RT_DIRS1; 1.
DR CDD; cd03714; RT_DIRS1; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR038900; TMC.
DR InterPro; IPR012496; TMC_dom.
DR PANTHER; PTHR23302:SF40; TRANSMEMBRANE CHANNEL-LIKE PROTEIN; 1.
DR PANTHER; PTHR23302; TRANSMEMBRANE CHANNEL-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR Pfam; PF07810; TMC; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000230233};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 798..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1323..1508
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 942..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1069..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2188..2274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..971
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1018
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1090
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2188..2205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2207..2253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2274 AA; 258893 MW; 5915EC64D44BBE59 CRC64;
MNGIEILPEG LRNNPLVQRR ASVFHDLITV FRKNTTQRFV QNTLDPFSPI IPWTAAYQPE
TDAFINKGDK QRETDEDGNP LTRQALLERI RQKKEVIGKL RCQAWSMTRK RRTLKLAQKY
LEQHESKVSR SHLYMEEMRK RARLMKRSFS NFKTYLIPWE SKIKRIESHF GSVVSSYFTF
LRWIVFVNIM ITLIAVAFVV LPETLADSVG NEGRNNRTKT RKQIPANEKV HADELAVVWH
YDGYLRYSPL FYGYYSDDPF LGNKIKYALP LAYFMVTLTI FAYSFFAILR KMAANARMSK
LSGSKAEQYI FNWKLFTGWD YTIGNSETAS NTVMAVVIKL RESIADIKKD SHGKFRLLQF
TLRVFANVVI CAMLGFSIYC IIFAVQKSQV QDDGNLFTKN QVPSVVSTIT HVFPMIFDLI
GRMENYHPRT ALRAHLGRVL ILYTVNYITL IFALFEKMTA LRDRVNSTST VKHHVKRQQG
GWNPNIQRPP PYASRAEVRQ MSEFLAANTR RFQTVSQRTT RSVTTPFTVA PQYGPFNVNN
PNAIFHNGTH STSFESQVLG PKVLPIFTPP PRKYQNYSPG NVGQQFGGPD FPKHQTYSKS
TPLPRVRTKP PWMFTTTIMP TVQKKPGSIS TPSAEQDTVE LDESKEIAAK DGSGNEQTIH
TNEAALRRNQ DGHNNDICWE TIIGQEIVKL VTMDLIFTIL SILVIDFLRG LWIKYCSSWW
CWDIETTFPE YGEFKVAENV LHIINNQGMI WLGLFFAPLL PAINNIKLII LMYIRGWAVM
TCNVPAREIF RASRSSNFYL GILLIWLLLC TLPVGFVIAS MSPSRSCGPF ARYEHFYTVV
TREIEKRVDQ TVLSYIRHIA SPGVVIPIIL FLILIIYFLF SLVRGLREAN TDLQAQLVHE
RTEEKKKIFE LAGGKKNKFE KDRDKKRSND YIPLIEQRRR EPWRQYHEQE ADNGLASDSS
EESDIGEEEE EERQPIAAYA LRSSETPPET LQVTAFHPSL GSLIENREME DEESSSGEPL
PMIHKSVSFQ GPSNIQMRQS ISTESCSQIS RSAIQVATPE EIRNFVASTI KETDLEEEPT
PDDKKLSSSK DVAPEFMPWP SADEAKALRE KMRLKAPLML TRASVEETPK GAKSDTDFRP
PVPIHRILCF SLKSGEKGRA KMADSVDKAT LKQFGEEILG KMAEMVKEVG TEKKKKSRIR
RDSSSFDMRA LSEAREVLGN TEARDSVVAE AEKEASSVSS ALSTATTPQI VNREGMSFPD
RLSAAIDFWE SICDVDWVLS VIEDGYKIQL NPNVALPEPQ GLRPSVARHK EFIVAEIERL
EAEGVLTRSD HQPRCVSPLH IVDQGKKKRM ILDLSELNES LVPPRFKLEN LKTAWPFLEE
ARFAATFDFK SGYHHIKIHK ESQDLLSFSL TNPPTAPYFS FRGMPFGLST APWLFTKIFK
VLVLKWRAEG IKIFLYLDDG LIVGKTEREV ARAVRKVRED LSCAGVCVAE EKSFWVPDAK
FTWLGYECDL VAREVRGTEK RMAKWQFALE ELRRSVAPTV LDRMKFLGCL ASFELVAGDV
GVGRARCLMQ TVGESQRKKN ESATVKKKKT PGEEREIEYW RERGSELLKR SIVEIERKFD
LFLYTDASAR GIGAVLKNER DDVLWKMSEL GDSDFDRQSS AWRELTAVKR AAEELVGKVN
GNIKVLVDSQ AAVSVLRRGS MKTELHELAE KVWEDLSRVG ESQFLWIPRE QNVDADEASR
NFDFDDWGVA DRVFRQAQRM WGEIKVDWFA DANNRKTELY FSRYPEFGTS GVNVFDHIER
AERMGCAWWV PPPVLLPHLL KIARKRRLRG VLVAPLWQSH VSYQSLVDKK GRFIRAIRDY
IVYEKNDKGA KRQFVEELKQ KAGEEFGHHI EKLKMIPFEA KAKSTAAAYK AENDKRNAWI
SEKKLPVDES SFLLYLLDRA KQIGSSALAK ISAAYQMANE GISAIGASFV SDLIKSKRRE
ESLLKKTVVE VTVEDVQKIT MLAMKEDSPE KDRDALLAIL SFNVMLRASE AAEIKWAGVK
QKDGMIEVHV EKAKNDQLRL GRSSFFNYEP GSDADILMCR WRLRTKGKCP YVFSHLNSSK
KLSKGAISTL STKMLAAIGK PGATHHCFRR GGANHMRRIG HSMEEIQCRG RWRSAAGLKA
YLTDVPTAQG CLQLKGAEEK RKYNIQATAE EDNKEETELP ESSKKRFRIS VSPTKTIQPA
STSRAQHKIV SQASSSSSIP HGRSATANKK TSLVLSPRAP RVQFDEDDSP RQID
//
