ID A0A2G5SPL7_9PELO Unreviewed; 769 AA.
AC A0A2G5SPL7;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN Name=Cni-pbo-4 {ECO:0000313|EMBL:PIC16902.1};
GN Synonyms=Cnig_chr_X.g23336 {ECO:0000313|EMBL:PIC16902.1};
GN ORFNames=B9Z55_023336 {ECO:0000313|EMBL:PIC16902.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC16902.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367,
CC ECO:0000256|RuleBase:RU003722}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC16902.1}.
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DR EMBL; PDUG01000006; PIC16902.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5SPL7; -.
DR Proteomes; UP000230233; Chromosome x.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF59; SODIUM_HYDROGEN EXCHANGER 1; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230233};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT TRANSMEM 84..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..495
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 769 AA; 86663 MW; CA7FCEDB37214C17 CRC64;
MDSNSSLIEQ TDRSVLLGQM MEKVNDLKMT EDELKTFLHL LKSNVSDDYS DEHVLEEHGH
VGNDSSHGGF HVFSFHWEYV KNDMVLVLFF IVIGLFKLGY HHTRFTKKIL PESCCLIIIG
VIFGFFFIGD DTHQSIKFLE FSTKVFFFYL LPPIILESAY SLKDRAFIDN IGTILLYAVL
GTVLNIVLLA AALLILIWIG VMGEINLSAM DIFTFSSLVA AVDPVAVLAV FQEVSVNKML
YFMVFGESLF NDAVTIVCYN LAIEFQTLPE FTWFHGLLGF VKFACVAIGG LIIGLICGAI
SSFITKFTTD VRVVEPVILF GMAYLAYLTS EMFHFSGIIA LIACGLFQTH YACCNVSYKS
FTSVMYITKV ASTLCESLIF IILGVMLVNE REWFWEDWHP VFSVVSVILC VVVRFGVTFF
LTYIVNKFTG GVRHISFQEQ FIMSYGGLRG AVSFSLAFMI TSSSDVKNTI LGATYAVILF
TNILQGSTIK LFVKWLNIRL AKKDDHFRLF NEFNSGMVHH LSQGIEGVCA NKNMSIINKC
SDFSKKYVRP ILEKNYDANA KKEGKLVELN RAVAMREALN NSPSQSSFKR QQTLDEMAES
GALPHDLMDE DHHHAGKVHT DREEIDERAN ELLKDVSTIR SLMNNPYEEC YLDRNLTHEE
EKEKARAKMK SLKSRAFNIS SVRKTIGFFG KKKSVRRNAT QQGLIHSAIA TLGVQSVDRP
STSSRLKPGI LDANRVVANK CQCQVAVVYP YSQFCSLIIG LLKRNVILR
//
