ID A0A2G5U1U4_9PELO Unreviewed; 1105 AA.
AC A0A2G5U1U4;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Amino acid permease/ SLC12A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Cni-kcc-2 {ECO:0000313|EMBL:PIC33517.1};
GN Synonyms=Cnig_chr_IV.g13470 {ECO:0000313|EMBL:PIC33517.1};
GN ORFNames=B9Z55_013470 {ECO:0000313|EMBL:PIC33517.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC33517.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC33517.1}.
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DR EMBL; PDUG01000004; PIC33517.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5U1U4; -.
DR STRING; 1611254.A0A2G5U1U4; -.
DR Proteomes; UP000230233; Chromosome iv.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF73; KAZACHOC, ISOFORM G; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230233};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 130..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 132..295
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 414..698
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 713..827
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 842..959
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 988..1105
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1105 AA; 122394 MW; 85F712463EF89BFE CRC64;
MTLTTTSMLR STSIPVKPVP PSQQFEPEPT SSTSTNTVTS RRSSGGGSGQ GLASKKPPNM
HINIPADEGA ERIPLCEQHS PLALYEQDYD TQGQKIGTML RKLSVYNATE ATSVEADEKP
KAAAAKMGTI MGVFLPCLQN IFGVLFFIRL AWIIGTAGIF QAFFVVLTCV SVTFLTSISL
SAIATNGVVP SGGPYYMISR NLGPELGGAV GILFYLGTTI AASMYITGAI EILLLYIYPQ
AKLFDDIYHN YRVLGTILLL ILGLIVMAGV KFVNRCALPL VIVVIFCILS AILGVFVRYD
GSDSLKFCMV GDRPVDLTSY YEKTKFVPNC TTDGLRDLFC SANGTCDHYY DRMKDIKVWK
ASGMPAIREE RAIKGIASGV FFDNLWPKYL RGGEVLSKDR KDKGDLNRGG HPSYIYAESV
TNFMILVGVF FPSATGIMAG SNRSGNLRDA AKSIPLGTLA AQNFSSFIYL LGVVLFGASV
SEMFIRDKYG RSAMGKLIIS EISWPFPQVI LFGCFMSTAG AGMQSLTGAP RLLQAIAADD
VIPFLKPFRK MDSRGEPIRA ILLTLAICEC GILIAVIENI TALITQFFLM CYLGVNAACA
LQSLLKSPGW RPGFRYFHWA LSMIGAILCV AVMFISAWHF ALIAIVIGAG VYKYIEYAGA
EKEWGDGLRG LGLSAARFAL LNLDDKPQHS RNWRPQLLVL APDVESANTN GILSFVSQLK
AGKGLTLVAH CMEGEYADNY LQAQAVQEKL KAMVKKNKIK GFCDVLVTSN VIEGISCLVQ
TSGLGGMRHN TVVLSWPDDW RADQEWAVAN KFVSAIRAIS AAKCAIMVPK YAEKFPANGT
KVSGYIDVWW VVHDGGLLML LPFLLRQHKT WKNTTVRLFA IAQMEDNNVQ MKTDLEKFLY
HLRIDAAVNV IEMTDSDISD YTYERTMKME ERNQYLKNLN KSDREKDIQN HLEIVTRERK
LSRINEEAPT VIPEQRNLEA VTEEQEQEEQ KSEKSLEKLE HKGVRFSDDE DGKEVKVGNG
TLERDREERQ RKRRYNVHKM HTAVKLNEMM RQKSSDAQLV FINLPGPPDA DSDSYYMDFI
DALTEGLDRV LLVRGTGAEV VTIYS
//
