ID A0A2G5U259_9PELO Unreviewed; 315 AA.
AC A0A2G5U259;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 13-SEP-2023, entry version 19.
DE RecName: Full=Secreted frizzled-related protein 1 {ECO:0008006|Google:ProtNLM};
GN Name=Cni-sfrp-1 {ECO:0000313|EMBL:PIC33627.1};
GN Synonyms=Cnig_chr_IV.g13539 {ECO:0000313|EMBL:PIC33627.1};
GN ORFNames=B9Z55_013539 {ECO:0000313|EMBL:PIC33627.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC33627.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC33627.1}.
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DR EMBL; PDUG01000004; PIC33627.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5U259; -.
DR Proteomes; UP000230233; Chromosome iv.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF148; SECRETED FRIZZLED-RELATED PROTEIN 1; 1.
DR Pfam; PF01392; Fz; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Reference proteome {ECO:0000313|Proteomes:UP000230233};
KW Signal {ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..315
FT /note="Secreted frizzled-related protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013768015"
FT DOMAIN 36..151
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 165..284
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 47..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 84..122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 115..139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 315 AA; 36078 MW; 6B670B18C3191916 CRC64;
MTLFPVLFLL LAFSVTNAYL EDSWAMFSSE RPVGPKCVDI PSNLSICNGI EYTQMRLPNI
LEHETVSEAI HASKDWESLL RLNCHPDTQR FLCSLFAPVC LMQMDRLILP CKSLCMAVKQ
GCENRMANYG FPWPEMLSCD KFEDDDMCIK PMQEAKPPAG STTTCTACSQ VATYENLVDQ
FCRSNLVLKG KVSRNSPTHI LVRNGRSMKK GERRKGVSEI EIRLTPESDS GCPCNVLPTK
GPNEKLLVMA SRQSDGKYLA NLVLPWQKEK NFKRAIHQFQ RLNCQSLGRE IRESAYRRPH
YYEMRRHNTG RYQMF
//
